Mulatero P, Bertello C, Verhovez A, Testa E, Puglisi E, Morello F, Monticone S, Fallo F, Veglio F
Divisione di Medicina Interna e Ipertensione, Università di Torino, Torino.
G Ital Nefrol. 2006 Jul-Aug;23(4):406-14.
The purpose of this review is to summarize the current knowledge regarding metabolic syndrome prevalence and features in primary aldosteronism. We will also discuss the link between aldosterone and the different metabolic changes typical of the metabolic syndrome. Hypertensive patients have a high prevalence of obesity, dyslipidemia and hyperglycaemia. These are risk factors for the metabolic syndrome, and are associated with an increased cardiovascular risk profile. In particular, insulin resistance seems to be the major alteration in patients affected by primary aldosteronism. We will then describe the experimental and clinical evidences of the role of aldosterone in the pathogenesis of insulin resistance. Higher rates of cardiovascular events have been recently reported in primary aldosteronism: they could be partly due to the increased prevalence of the metabolic syndrome in this disorder.
本综述的目的是总结目前关于原发性醛固酮增多症中代谢综合征患病率及特征的知识。我们还将讨论醛固酮与代谢综合征典型的不同代谢变化之间的联系。高血压患者肥胖、血脂异常和高血糖的患病率较高。这些是代谢综合征的危险因素，并与心血管风险增加相关。特别是，胰岛素抵抗似乎是原发性醛固酮增多症患者的主要改变。然后我们将描述醛固酮在胰岛素抵抗发病机制中作用的实验和临床证据。最近报道原发性醛固酮增多症中心血管事件发生率较高：这可能部分归因于该疾病中代谢综合征患病率的增加。
