金催化及N-碘代琥珀酰亚胺介导的γ-取代烯丙酰胺环化反应
Gold-catalyzed and N-iodosuccinimide-mediated cyclization of gamma-substituted allenamides.
作者信息
Hyland Christopher J T, Hegedus Louis S
机构信息
Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, USA.
出版信息
J Org Chem. 2006 Oct 27;71(22):8658-60. doi: 10.1021/jo061340r.
PMID:17064053
Abstract
Chiral gamma-substituted allenamides have been shown to undergo efficient gold-catalyzed and N-iodosuccinimide-mediated cyclization to highly functionalized dihydrofurans. These reactions proceed rapidly and without loss of stereochemistry.
摘要
手性γ-取代烯丙酰胺已被证明能在金催化和N-碘代琥珀酰亚胺介导下高效环化生成高度官能化的二氢呋喃。这些反应进行迅速且不会损失立体化学结构。
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