通过铜催化卤代烯丙基与酰胺、氨基甲酸酯和脲的偶联反应合成联烯酰胺。
Synthesis of allenamides by copper-catalyzed coupling of allenyl halides with amides, carbamates, and ureas.
作者信息
Trost Barry M, Stiles Dylan T
机构信息
Department of Chemistry, Stanford University, Stanford, California 94305-5080, USA.
出版信息
Org Lett. 2005 May 26;7(11):2117-20. doi: 10.1021/ol050395x.
PMID:15901148
Abstract
[reaction: see text]. A variety of N-substituted allenes have been synthesized by the copper-catalyzed coupling reaction between allenyl halides and amides, carbamates, and ureas. The reactions proceed in good to excellent yield using 7 mol % copper thiophenecarboxylate and 15 mol % of a diamine catalyst.
摘要
[反应：见正文]。通过铜催化的卤代丙二烯与酰胺、氨基甲酸酯和脲之间的偶联反应，已合成了多种N-取代丙二烯。使用7摩尔%的噻吩羧酸铜和15摩尔%的二胺催化剂，反应以良好至优异的产率进行。
Zotero 插件