Emerging drug therapies for systemic lupus erythematosus.

Despite the tremendous improvement in survival of systemic lupus erythematosus (SLE) in the past few decades, manifestations of the disease that are refractory to conventional therapies and treatment-related complications are still major causes of mortality and morbidity. In recent years, we have seen an explosive development of newer therapeutic modalities for various rheumatic diseases including SLE. Novel therapies for SLE should aim at targeting more specifically the immunopathogenetic pathways to achieve higher efficacy and reduce therapy related toxicities. This article reviews the emerging therapeutic modalities that have been used or are being tried in patients with SLE.