Abdulkader M, Abdulla K, Rakha E, Kaye P
Department of Histopathology, Queen's Medical Centre, University Hospital NHS Trust, Nottingham, UK.
Histopathology. 2006 Nov;49(5):487-92. doi: 10.1111/j.1365-2559.2006.02533.x.
To determine the value of routine staining of colorectal cancer (CRC) specimens with elastic stains.
Four hundred and ninety-eight cases of CRC were included. In 208 cases, vascular invasion (VI) was assessed using elastic stains [Elastic van Gieson or Elastin haematoxylin and eosin (H&E)] that were introduced as routine staining in CRC in our hospital. As a control, 290 cases in which VI was assessed solely on H&E staining were included. The site, stage and presence of vascular invasion were determined in both groups. The cost, time and workload resulting from the addition of these stains were also taken into account. The sensitivity of detection of VI in CRC was significantly improved after the introduction of these elastic stains in our routine practice (46.2% compared with 35.5% in the control group; P = 0.014). Particular improvement was noted in Dukes' stage A and B. We also noted that the net benefits gained from the introduction of these special stains outweighed the small extra cost and effort and, in addition, saved time for the reporting pathologists.
Routine elastic stains are very useful and practical in evaluation of VI status in CRC and we recommend implementing these stains in routine pathological practice to improve patient care.
确定对结直肠癌（CRC）标本进行弹性染色常规染色的价值。
纳入498例CRC病例。其中208例使用弹性染色法（弹性范吉森染色法或弹性苏木精和伊红染色法）评估血管侵犯（VI）情况，这两种弹性染色法在我院已被引入作为CRC的常规染色方法。作为对照，纳入290例仅通过苏木精和伊红染色评估VI的病例。确定两组病例的肿瘤部位、分期及血管侵犯情况。同时考虑添加这些染色剂所产生的成本、时间和工作量。在我们的常规实践中引入这些弹性染色法后，CRC中VI检测的敏感性显著提高（46.2%，对照组为35.5%；P = 0.014）。在杜克分期A和B期有特别明显的改善。我们还注意到，引入这些特殊染色剂带来的净收益超过了额外的少量成本和工作量，此外，还为病理报告医生节省了时间。
常规弹性染色在评估CRC的VI状态方面非常有用且实用，我们建议在常规病理实践中采用这些染色方法以改善患者护理。
