豚鼠膀胱中速激肽受体的特性研究

Characterization of tachykinin receptors in urinary bladder from guinea pig.

作者信息

Shinkai M, Takayanagi I

机构信息

Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences, Chiba, Japan.

出版信息

Jpn J Pharmacol. 1990 Oct;54(2):241-3. doi: 10.1254/jjp.54.241.

DOI:10.1254/jjp.54.241

PMID:1706445

Abstract

The contractile responses to substance P (SP), neurokinin A (NKA), Tyro-neurokinin B (Tyr-NKB), senktide (NK3 receptor selective agonist) and SP methyl ester (SPOMe, NK1 receptor selective agonist) were investigated in detrusor strips from guinea pigs. Except for senktide, all drugs induced a concentration-related contraction with the following rank order of potency: SPOMe greater than SP greater than NKA greater than or equal to Tyr-NKB. After desensitization of NK1 receptors with SPOMe, the rank order of potency was NKA greater than or equal to Tyr-NKB greater than SP greater than SPOMe. Both NK1 and NK2 receptors exist in the detrusor strip from guinea pigs.

摘要

在豚鼠逼尿肌条上研究了对P物质（SP）、神经激肽A（NKA）、酪胺神经激肽B（Tyr-NKB）、senktide（NK3受体选择性激动剂）和SP甲酯（SPOMe，NK1受体选择性激动剂）的收缩反应。除senktide外，所有药物均引起浓度依赖性收缩，其效力顺序如下：SPOMe大于SP大于NKA大于或等于Tyr-NKB。用SPOMe使NK1受体脱敏后，效力顺序为NKA大于或等于Tyr-NKB大于SP大于SPOMe。豚鼠逼尿肌条中同时存在NK1和NK2受体。