Do antisaccade deficits in schizophrenia provide evidence of a specific inhibitory function?
作者信息
Donohoe Gary, Reilly Richard, Clarke Sarah, Meredith Stephen, Green Barry, Morris Derek, Gill Michael, Corvin Aiden, Garavan Hugh, Robertson Ian H
机构信息
Neuropsychiatric Genetics Research Group, Department of Psychiatry, & Institute of Molecular Medicine, Trinity College Dublin, Dublin, Ireland.
出版信息
J Int Neuropsychol Soc. 2006 Nov;12(6):901-6. doi: 10.1017/S135561770606108X.
BACKGROUND
Despite its inhibitory control requirements, antisaccade deficits have been consistently associated with working memory impairments in schizophrenia. We investigated whether variance in antisaccade performance could be better accounted for in terms of a specific inhibitory function.
METHOD
We assessed 48 clinically stable out-patients with schizophrenia on an antisaccade task, as well as on measures of spatial and verbal working memory, sustained selective attention, and a simple motoric go/no-go measure of response inhibition.
RESULTS
In a stepwise multiple regression analysis, go/no-go task performance accounted for a considerably greater percentage of variance in antisaccade performance (25.3%) than either working memory (8.4%) or sustained selective attention task (9.1%).
DISCUSSION
We conclude that antisaccade deficits in schizophrenia appear to be better understood in terms of a specific deficit of inhibitory control than in terms of more general difficulties with context maintenance or goal neglect.
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