Albuquerque M, de Lima J P
Department of Orthopedics and Traumatic Surgery, University Hospital, Portugal.
Lymphology. 1990 Dec;23(4):215-8.
Whereas joint lymphatics are inaccessible to conventional (oil-contrast) lymphography, articular lymphatic dysfunction can be assessed by lymphoscintigraphy (isotope lymphography). Using 99mTc-labeled dextran (molecular weight-70,000 daltons), we performed dynamic lymphoscintigraphy in 38 patients with degenerative osteoarthropathy of the knee. Comparison with the normal (contralateral knee) in 25 patients demonstrated that tracer disappeared at 24 hours more slowly from the abnormal side (86.5 +/- 3.3% retention in the abnormal joint compared with 77.1 +/- 4.6%; p less than 0.01), but accumulated more intensely in regional lymph nodes on the pathologic side (3.8 +/- 2.4% vs 1.9 +/- 0.3%; p less than 0.01). The findings suggest deranged macromolecular transport and lymphatic dysfunction in degenerative knee joint disease.
由于传统的（油造影）淋巴管造影无法显示关节淋巴管，关节淋巴功能障碍可通过淋巴闪烁造影（同位素淋巴管造影）进行评估。我们使用99mTc标记的葡聚糖（分子量70,000道尔顿），对38例膝关节退行性骨关节炎患者进行了动态淋巴闪烁造影。与25例正常（对侧膝关节）患者对比显示，示踪剂在异常侧24小时消失得更慢（异常关节留存率为86.5±3.3%，而正常关节为77.1±4.6%；p<0.01），但在病理侧区域淋巴结中的聚集更为强烈（3.8±2.4%对1.9±0.3%；p<0.01）。这些发现提示，在膝关节退行性疾病中存在大分子转运紊乱和淋巴功能障碍。
