Bao Yu-qian, Jia Wei-ping, Chen Lei, Lu Jun-xi, Xiang Kun-san
Shanghai Clinical Center of Diabetes, Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, The Sixth People's Hospital affiliated to Shanghai Jiaotong University, Shanghai 200233, China.
Zhonghua Yi Xue Za Zhi. 2006 Aug 15;86(30):2105-9.
To investigate the relationship between serum C-reactive protein (CRP) and metabolic disorders in individuals in Shanghai communities and to assess the value of CRP level on the risk of metabolic disorders.
A total of 5502 individuals (males 2379, females 3123) aged over 20 years with complete baseline data on metabolic syndrome (MS) and serum CRP from 1998 to 2001 in two communities of Shanghai were included. Highly sensitive CRP was tested by kinetics nephelometry. Quartiles of concentration of CRP were computed. Hyperglycemia (diabetes or impaired glucose regulation), hypertension, dyslipidemia, central obesity and MS were defined by WHO (1999) working definition of MS. Logistic regression model was used to estimate the relation between CRP level and relative risks of metabolic disorders.
(1) In this two communities based population the prevalences of metabolic syndrome and its components were as follow: hyperglycemia 21.63% (diabetes 9.21%, impaired glucose regulation 12.41%), hypertension 32.95%, high triglyceride (TG)/low high-density lipoprotein cholesterol (HDL-C) 46.04%, central obesity 40.68% and metabolic syndrome 13.98%. (2) Serum CRP level was gradually elevated with the increment of ages in both men and women (P < 0.01). (3) Serum CRP level was increased with the increment of the components of metabolic disorders (P < 0.01). In individuals with MS, CRP level was higher than in those with 1 or 2 components of metabolic disorders (P < 0.01). (4) The highest quartile of CRP was 2.11 mg/L in men and 2.22 mg/L in women. (5) Compared with those in the lowest quartile, men in the highest quartile had increased relative risk of hyperglycemia (3.8 times), central obesity (5.5 times), hypertension (2.8 times), hyper triglyceride (1.3 times), low HDL-C (1.5 times) and MS (10 times). Similarly, women in the highest quartile had increased relative risk of hyperglycemia (7.7 times), central obesity (12.2 times), hypertension (6.1 times), hypertriglyceride (5.6 times), low HDL-C (1.1 times) and MS (8.5 times).
(1) CRP level was related to the increment of age. (2) Individuals with more components of metabolic syndrome had higher serum CRP level. (3) The incidence of metabolic syndrome was increased with the increment of CRP level. The risk of metabolic disorders including hyperglycemia, hypertension, dyslipidemia, central obesity and metabolic syndrome was significantly elevated in men with CRP level over 2.11 mg/L and women with CRP level over 2.22 mg/L.
探讨上海社区人群血清C反应蛋白（CRP）与代谢紊乱之间的关系，并评估CRP水平对代谢紊乱风险的价值。
纳入1998年至2001年来自上海两个社区的5502名20岁以上个体（男性2379名，女性3123名），他们有关于代谢综合征（MS）和血清CRP的完整基线数据。采用动力学散射比浊法检测高敏CRP。计算CRP浓度的四分位数。高血糖（糖尿病或糖调节受损）、高血压、血脂异常、中心性肥胖和MS根据世界卫生组织（1999年）MS工作定义进行定义。采用Logistic回归模型估计CRP水平与代谢紊乱相对风险之间的关系。
（1）在这个基于两个社区的人群中，代谢综合征及其组分的患病率如下：高血糖21.63%（糖尿病9.21%，糖调节受损12.41%），高血压32.95%，高甘油三酯（TG）/低高密度脂蛋白胆固醇（HDL-C）46.04%，中心性肥胖40.68%，代谢综合征13.98%。（2）男性和女性的血清CRP水平均随年龄增长而逐渐升高（P<0.01）。（3）血清CRP水平随代谢紊乱组分的增加而升高（P<0.01）。患有MS的个体，其CRP水平高于有1种或2种代谢紊乱组分的个体（P<0.01）。（4）男性CRP最高四分位数为2.11mg/L，女性为2.22mg/L。（5）与最低四分位数者相比，最高四分位数的男性患高血糖（3.8倍）、中心性肥胖（5.5倍）、高血压（2.8倍）、高甘油三酯（1.3倍）、低HDL-C（1.5倍）和MS（10倍）的相对风险增加。同样，最高四分位数的女性患高血糖（7.7倍）、中心性肥胖（1十二点二倍）、高血压（6.1倍）、高甘油三酯（5.6倍）、低HDL-C（1.1倍）和MS（8.5倍）的相对风险增加。
（1）CRP水平与年龄增长有关。（2）代谢综合征组分越多的个体血清CRP水平越高。（3）代谢综合征的发病率随CRP水平的升高而增加。CRP水平超过2.11mg/L的男性和超过2.22mg/L的女性患包括高血糖、高血压、血脂异常、中心性肥胖和代谢综合征在内的代谢紊乱风险显著升高。
