Huang Tiao-Lai, Lin Fu-Chen
Department of Psychiatry, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, 123, Ta-Pei Rd, Niao-Sung, Kaohsiung 833, Taiwan.
Prog Neuropsychopharmacol Biol Psychiatry. 2007 Mar 30;31(2):370-2. doi: 10.1016/j.pnpbp.2006.09.010. Epub 2006 Oct 24.
The serum high-sensitivity C-reactive protein (hsCRP) levels in patients with major depressive disorder and bipolar I disorder in acute phases were investigated. During a 1-year period, a total of 67 participants including 23 patients with major depressive disorder, 13 patients with bipolar I disorder (manic episode) and 31 healthy controls were recruited in this study. The diagnoses of mental disorders in participants were made by one psychiatrist according to the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID). Both patient groups with major depression and bipolar disorder had higher mean serum hsCRP levels than the healthy control group. Using analysis of covariance with age adjustment, patients with bipolar I disorders still had significantly higher hsCRP levels than healthy controls (P=0.043). However, patients with major depression did not have significantly higher hsCRP levels than healthy controls (P=0.172). These results suggest that patients with bipolar I disorder might have a more severe inflammation reaction than patients without major depression. However, larger samples and adequate statistical methods are needed to prove these results.
对重度抑郁症和双相I型障碍患者急性期的血清高敏C反应蛋白（hsCRP）水平进行了调查。在1年的时间里，本研究共招募了67名参与者，其中包括23名重度抑郁症患者、13名双相I型障碍（躁狂发作）患者和31名健康对照者。参与者的精神障碍诊断由一名精神科医生根据《精神疾病诊断与统计手册》第四版轴I障碍的结构化临床访谈（SCID）做出。重度抑郁症和双相情感障碍患者组的血清hsCRP平均水平均高于健康对照组。通过年龄调整的协方差分析，双相I型障碍患者的hsCRP水平仍显著高于健康对照组（P=0.043）。然而，重度抑郁症患者的hsCRP水平与健康对照组相比没有显著升高（P=0.172）。这些结果表明，双相I型障碍患者可能比无重度抑郁症的患者有更严重的炎症反应。然而，需要更大的样本和适当的统计方法来证实这些结果。
