Nankoe Sharif R, Sever Sanja
Nephrology Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA.
Trends Cell Biol. 2006 Dec;16(12):607-9. doi: 10.1016/j.tcb.2006.10.004. Epub 2006 Oct 24.
During clathrin-mediated endocytosis, dynamin promotes the formation of clathrin-coated vesicles, but its mode of action is unresolved. In a recent study, Macia and colleagues made use of dynasore, a dynamin-specific inhibitor, to show that dynamin plays a dual role in endocytosis: they confirmed that dynamin is involved in detaching fully formed coated pits from the membrane, and also propose a new role for dynamin earlier in the process at the point of invagination.
在网格蛋白介导的内吞作用过程中，发动蛋白促进网格蛋白包被小泡的形成，但其作用方式尚未明确。在最近的一项研究中，马西亚及其同事利用发动蛋白特异性抑制剂dynasore表明，发动蛋白在内吞作用中发挥双重作用：他们证实发动蛋白参与将完全形成的包被小窝从膜上分离，并且还提出发动蛋白在该过程早期内陷点处有一个新的作用。
