Bitar Zouheir Ibrahim, Ahmed Sherif, Amin Amin Elsayed, Jamal Khaled, Ridha Mustafa
Adan Hospital, Ministry of Health, Kuwait.
Prim Care Respir J. 2006 Dec;15(6):342-5. doi: 10.1016/j.pcrj.2006.08.011. Epub 2006 Oct 24.
Mitral valve prolapse (MVP) has been described as a common diagnosis and has been reported in 50% of patients with primary spontaneous pneumothorax (PSP). The purpose of this study was to determine the prevalence of MVP -- as diagnosed by 2D-echocardiography criteria -- in spontaneous pneumothorax.
A case-control study of 24 patients with PSP, and 40 age-matched controls. All cases underwent 2D-echocardiography by a certified cardiologist. Echocardiography and demographic features of both groups were compared and analyzed using Fisher's exact test. Classic MVP was defined as superior displacement of the mitral leaflets of more than 2 mm during systole and as a maximal leaflet thickness of at least 5 mm during diastasis, and non-classic prolapse was defined as displacement of more than 2 mm with a maximal thickness of less than 5 mm.
MVP was found in 9 of the 24 patients (37.5%) who suffered PSP, compared to 3 out of the 40 (7.5%) age-matched controls (P=0.008). The body mass index (BMI) (weight/height2) was lower in the group with pneumothorax (P=0.001).
In this study, applying an updated definition of MVP, the prevalence of MVP in PSP was lower than previously reported, but was still significantly higher than in the control group.
二尖瓣脱垂（MVP）已被描述为一种常见诊断，据报道在50%的原发性自发性气胸（PSP）患者中存在。本研究的目的是确定通过二维超声心动图标准诊断的MVP在自发性气胸中的患病率。
对24例PSP患者和40例年龄匹配的对照者进行病例对照研究。所有病例均由认证心脏病专家进行二维超声心动图检查。使用Fisher精确检验对两组的超声心动图和人口统计学特征进行比较和分析。经典MVP定义为收缩期二尖瓣叶向上移位超过2mm，舒张期最大叶厚度至少5mm，非经典脱垂定义为移位超过2mm且最大厚度小于5mm。
24例PSP患者中有9例（37.5%）发现MVP，而40例年龄匹配的对照者中有3例（7.5%）（P = 0.008）。气胸组的体重指数（BMI）（体重/身高²）较低（P = 0.001）。
在本研究中，应用MVP的更新定义，PSP中MVP的患病率低于先前报道，但仍显著高于对照组。
