Margaliot S Z, Barzilay J, Bar-David M, Lewis B S, Froom P, Forecast D, Gross M
Chest. 1986 Jan;89(1):93-4. doi: 10.1378/chest.89.1.93.
We searched for mitral valve prolapse in patients with spontaneous pneumothorax to test the hypothesis that both may be part of a common disorder of connective tissue. Echocardiographic mitral valve prolapse was found in 11 (50 percent) of 22 patients who had suffered spontaneous pneumothorax compared to four (10 percent) of 40 age-matched control subjects (p less than 0.01). The body mass index (BMI) (weight/height2) was lower (p less than 0.001) in the group with pneumothorax; in five patients who were the thinnest in the study (BMI less than 2 standard deviations lower than mean normal value), mitral valve prolapse was present in four. The finding of a strong association of spontaneous pneumothorax with mitral valve prolapse, especially in subjects with an abnormal body build, suggests that in many patients, spontaneous pneumothorax may be a manifestation of a systemic abnormality of connective tissue.
我们对特发性气胸患者进行了二尖瓣脱垂检查，以验证二者可能均为结缔组织常见疾病一部分的假说。在22例特发性气胸患者中，11例（50%）经超声心动图检查发现有二尖瓣脱垂，而40例年龄匹配的对照者中仅有4例（10%）有二尖瓣脱垂（p<0.01）。气胸组的体重指数（BMI）（体重/身高²）较低（p<0.001）；在本研究中最瘦的5例患者（BMI比正常均值低2个标准差以上）中，有4例存在二尖瓣脱垂。特发性气胸与二尖瓣脱垂之间存在密切关联，尤其是在体型异常的患者中，这一发现提示，在许多患者中，特发性气胸可能是结缔组织系统性异常的一种表现。
