Isobe Koichi, Ejima Yasuo, Tokumaru Sunao, Shikama Naoto, Suzuki Gen, Takemoto Mitsuhiro, Tsuchida Emiko, Nomura Miwako, Shibamoto Yuta, Hayabuchi Naofumi
Japanese Society for Therapeutic Radiology and Oncology Study Group, and Department of Radiology, Chiba University Hospital, 1-8-01 Inohana, Chuo-ku, Chiba 260-8677, Japan.
Leuk Lymphoma. 2006 Sep;47(9):1800-5. doi: 10.1080/10428190600632881.
This study evaluated the clinical features and treatment outcome of 15 patients with primary intraocular lymphoma. There were nine females, with a median age of 68 years. Thirteen patients presented with bilateral lesions and median time from the onset of symptoms to diagnosis was 12 months. All but one showed the B-cell phenotype. All patients received radiation therapy (RT) with a median of 41 Gy and 10 were administered chemotherapy as well. Three patients were treated with high-dose methotrexate and nine received prophylactic cranial irradiation (PCI) with a median of 30.6 Gy. Thirteen patients obtained a complete remission. The 2-year overall and disease free survival were 74% and 58%, respectively. Although only one patient experienced local recurrence, PCI did not prevent intracranial recurrence. One patient developed a grade 3 cognitive disturbance. It was concluded that ocular RT was effective to control primary lesions. However, some modifications are indispensable to improve outcomes.
本研究评估了15例原发性眼内淋巴瘤患者的临床特征和治疗结果。其中有9名女性，中位年龄为68岁。13例患者表现为双侧病变，从症状出现到诊断的中位时间为12个月。除1例患者外，所有患者均表现为B细胞表型。所有患者均接受了中位剂量为41 Gy的放射治疗（RT），其中10例患者还接受了化疗。3例患者接受了大剂量甲氨蝶呤治疗，9例患者接受了中位剂量为30.6 Gy的预防性颅脑照射（PCI）。13例患者获得完全缓解。2年总生存率和无病生存率分别为74%和58%。尽管只有1例患者出现局部复发，但PCI并不能预防颅内复发。1例患者出现3级认知障碍。研究得出结论，眼部放疗对控制原发性病变有效。然而，为了改善治疗结果，一些改进措施是必不可少的。
