Abdi Fatemeh, Mohammadi S Saeed, Falavarjani Khalil Ghasemi
Eye Research Center, The Five Senses Institute, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
J Ophthalmic Vis Res. 2021 Oct 25;16(4):657-669. doi: 10.18502/jovr.v16i4.9756. eCollection 2021 Oct-Dec.
Intravitreal methotrexate (MTX) has been proven to be an effective treatment for various intraocular diseases. In this article, a comprehensive review was performed on intravitreal applications of methotrexate. Different aspects of the administration of intravitreal MTX for various clinical conditions such as intraocular tumors, proliferative vitreoretinopathy, diabetic retinopathy, age-related macular degeneration, and uveitis were reviewed and the adverse effects of intravitreal injection of MTX were discussed. The most common indications are intraocular lymphoma and uveitis. Other applications remain challenging and more studies are needed to establish the role of intravitreal MTX in the management of ocular diseases.
玻璃体内注射甲氨蝶呤（MTX）已被证明是治疗各种眼内疾病的有效方法。本文对甲氨蝶呤的玻璃体内应用进行了全面综述。回顾了玻璃体内注射MTX在各种临床情况下的不同应用方面，如眼内肿瘤、增殖性玻璃体视网膜病变、糖尿病视网膜病变、年龄相关性黄斑变性和葡萄膜炎，并讨论了玻璃体内注射MTX的不良反应。最常见的适应证是眼内淋巴瘤和葡萄膜炎。其他应用仍具有挑战性，需要更多研究来确定玻璃体内MTX在眼部疾病管理中的作用。
