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新型核苷酸4KNTP在肾衰竭儿童红细胞中浓度较高：与血浆中其他假定前体的蓄积情况比较

The novel nucleotide 4KNTP, in high concentrations in erythrocytes of renal failure children: a comparison with accumulation of other putative precursors in the plasma.

作者信息

Carrey E A, Synesiou E, Simmonds H A, Fairbanks L D

机构信息

Institute of Child Health, University College London, London, UK.

出版信息

Nucleosides Nucleotides Nucleic Acids. 2006;25(9-11):1051-4. doi: 10.1080/15257770600890947.

DOI:10.1080/15257770600890947
PMID:17065063
Abstract

We have measured the concentrations of metabolites related to the turnover of NAD, which accumulate in the blood of children with renal failure. One is a novel nucleotide, identified as the N1-riboside triphosphate of 4-pyridone-3-carboxamide (4PYTP), also described as 4KNTP, which accumulates in the erythrocytes in parallel with renal failure.

摘要

我们已经测量了与NAD周转相关的代谢物浓度，这些代谢物在肾衰竭儿童的血液中会累积。其中一种是一种新型核苷酸，被鉴定为4-吡啶酮-3-甲酰胺的N1-核糖三磷酸（4PYTP），也被称为4KNTP，它在红细胞中的累积与肾衰竭程度平行。

相似文献

1
The novel nucleotide 4KNTP, in high concentrations in erythrocytes of renal failure children: a comparison with accumulation of other putative precursors in the plasma.新型核苷酸4KNTP在肾衰竭儿童红细胞中浓度较高：与血浆中其他假定前体的蓄积情况比较
Nucleosides Nucleotides Nucleic Acids. 2006;25(9-11):1051-4. doi: 10.1080/15257770600890947.
2
4-Pyridone-3-carboxamide-1-β-D-ribonucleoside triphosphate (4PyTP), a novel NAD metabolite accumulating in erythrocytes of uremic children: a biomarker for a toxic NAD analogue in other tissues?4-吡啶酮-3-羧酰胺-1-β-D-核糖核苷三磷酸（4PyTP），一种在尿毒症儿童红细胞中蓄积的新型 NAD 代谢物：其他组织中有毒 NAD 类似物的生物标志物？
Toxins (Basel). 2011 Jun;3(6):520-37. doi: 10.3390/toxins3060520. Epub 2011 Jun 7.
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An unusual pyridine nucleotide accumulating in erythrocytes: its identity and positive correlation with degree of renal failure.一种在红细胞中积累的异常吡啶核苷酸：其身份及与肾衰竭程度的正相关。
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A novel nucleotide found in human erythrocytes, 4-pyridone-3-carboxamide-1-beta-D-ribonucleoside triphosphate.一种在人类红细胞中发现的新型核苷酸，4-吡啶酮-3-甲酰胺-1-β-D-核糖核苷三磷酸。
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4-pyridone-3-carboxamide ribonucleoside triphosphate accumulating in erythrocytes in end stage renal failure originates from tryptophan metabolism.终末期肾衰竭患者红细胞中积累的4-吡啶酮-3-羧酰胺核糖核苷三磷酸源自色氨酸代谢。
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Origin and characteristics of an unusual pyridine nucleotide accumulating in erythrocytes: positive correlation with degree of renal failure.红细胞中一种异常积累的吡啶核苷酸的起源与特性：与肾衰竭程度呈正相关。
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Metabolism of 4-pyridone-3-carboxamide-1-beta-D-ribonucleoside triphosphate and its nucleoside precursor in the erythrocytes.4-吡啶酮-3-甲酰胺-1-β-D-核糖核苷三磷酸及其核苷前体在红细胞中的代谢
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引用本文的文献

1
The Biochemical Pathways of Nicotinamide-Derived Pyridones.烟酰胺衍生吡啶酮的生物化学途径。
Int J Mol Sci. 2021 Jan 24;22(3):1145. doi: 10.3390/ijms22031145.
2
4-Pyridone-3-carboxamide-1-β-D-ribonucleoside triphosphate (4PyTP), a novel NAD metabolite accumulating in erythrocytes of uremic children: a biomarker for a toxic NAD analogue in other tissues?4-吡啶酮-3-羧酰胺-1-β-D-核糖核苷三磷酸（4PyTP），一种在尿毒症儿童红细胞中蓄积的新型 NAD 代谢物：其他组织中有毒 NAD 类似物的生物标志物？
Toxins (Basel). 2011 Jun;3(6):520-37. doi: 10.3390/toxins3060520. Epub 2011 Jun 7.