Adenosine kinase from rat liver: new biochemical properties.
作者信息
Leoncini R, Vannoni D, Santoro A, Giglioni S, Carli R, Marinello E
机构信息
Department of Internal Medicine, Endocrine-Metabolic Sciences and Biochemistry University of Siena, Siena, Italy.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2006;25(9-11):1107-12. doi: 10.1080/15257770600894139.
Adenosine kinase is a well-known enzyme which catalyzes the phosphorylation of adenosine to AMP: Its metabolic and kinetic properties are well studied. Here, we report new properties of rat liver enzyme, demonstrating a new reaction: ADP can be a phosphate donor instead ATP, according to the reaction: adenosine + ADP --> 2AMP) demonstrating the efficiency of AdK to phosphorylate adenosine, also starting from ADP. Cells could exploited this property in situations in which ATP levels are strongly decreased and ADP decreases slowly.
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