Madewell B R, Deitch A D, Higgins R J, Marks S L, deVere White R W
Department of Veterinary Medicine, School of Veterinary Medicine, University of California, Davis 95616.
Prostate. 1991;18(2):173-9. doi: 10.1002/pros.2990180210.
Flow cytometric DNA measurements were carried out on 45 formalin-fixed, paraffin-embedded canine prostate tissues. The tissues were categorized as normal, hyperplastic, or neoplastic on the basis of light microscopic examination, and DNA ploidy was compared with histologic classification. Ten normal prostate samples showed diploid DNA histograms, but with proliferation greater than that found in the normal human prostate. Thirteen specimens of benign prostate hyperplasia showed diploid or near-diploid DNA histograms. Of 22 prostatic carcinomas, 12 were diploid and 10 were aneuploid, with the majority of the aneuploidy being near-triploid. The frequency of DNA aneuploidy recognized in canine prostatic carcinoma is similar to findings in human prostatic carcinoma if all their grades of malignancy are included.
对45份福尔马林固定、石蜡包埋的犬前列腺组织进行了流式细胞术DNA检测。根据光学显微镜检查将这些组织分类为正常、增生或肿瘤性，并将DNA倍性与组织学分类进行比较。10个正常前列腺样本显示二倍体DNA直方图，但增殖程度高于正常人类前列腺。13例良性前列腺增生标本显示二倍体或近二倍体DNA直方图。在22例前列腺癌中，12例为二倍体，10例为非整倍体，大多数非整倍体接近三倍体。如果将犬前列腺癌所有恶性程度等级都包括在内，其DNA非整倍体的频率与人类前列腺癌的研究结果相似。
