Frauenhoffer E E, Ro J Y, el-Naggar A K, Ordóñez N G, Ayala A G
Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston 77030.
Am J Clin Pathol. 1991 Apr;95(4):446-53. doi: 10.1093/ajcp/95.4.446.
Clear cell cribriform hyperplasia (CCCH) of the prostate is an unusual form of benign prostatic hyperplasia characterized by a nodular proliferation of clear cells with small, uniform nuclei. The authors studied 15 cases of CCCH by immunohistochemistry and 13 of them by DNA flow cytometry to establish the immunohistochemical and DNA profile of this lesion. Patients ranged in age from 58 to 88 years (mean, 68 years). Follow-up of a mean of 22 months showed all patients alive with no evidence of malignant prostatic disease. All 13 CCCHs showed diploid DNA content; in contrast, among 4 papillary/cribriform carcinomas of the prostate used for comparison, 3 were aneuploid and 1 was diploid. A basal cell layer was demonstrated in all 15 CCCHs by the use of the 34 beta E12 anti-high-molecular-weight keratin antibody (EAB-903) that reacts with the basal cells but not with the acinar cells of the prostate. A continuous basal cell layer was not evident in the carcinomas. The blandness of the epithelium, the well-defined nodular configuration, the presence of a basal cell layer demonstrable by immunocytochemistry, and the lack of aneuploidy as determined by DNA flow cytometry together lend support to the concept that CCCH is a benign lesion.
前列腺透明细胞筛状增生（CCCH）是良性前列腺增生的一种不常见形式，其特征为具有小而均匀细胞核的透明细胞呈结节状增生。作者通过免疫组织化学研究了15例CCCH病例，并通过DNA流式细胞术研究了其中13例，以确定该病变的免疫组织化学和DNA特征。患者年龄在58至88岁之间（平均68岁）。平均22个月的随访显示，所有患者均存活，无前列腺恶性疾病证据。所有13例CCCH均显示二倍体DNA含量；相比之下，用于比较的4例前列腺乳头状/筛状癌中，3例为非整倍体，1例为二倍体。通过使用与前列腺基底细胞而非腺泡细胞反应的34βE12抗高分子量角蛋白抗体（EAB-903），在所有15例CCCH中均证实存在基底细胞层。在癌组织中未发现连续的基底细胞层。上皮细胞的温和性、明确的结节状结构、免疫细胞化学可证实的基底细胞层的存在以及DNA流式细胞术确定的无非整倍体现象，共同支持了CCCH是一种良性病变的观点。
