儿童急性白血病中ABO血型的分布
Distribution of ABO blood groups in childhood acute leukemia.
作者信息
Alavi Samin, Ashraf Haleh, Rashidi Armin, Hosseini Negin, Abouzari Mehdi, Naderifar Mehdi
机构信息
Shaheed Beheshti University of Medical Sciences, Tehran, Iran.
出版信息
Pediatr Hematol Oncol. 2006 Dec;23(8):611-7. doi: 10.1080/08880010600907221.
The distribution of ABO blood groups was determined in a multicenter study of 682 pediatric patients with acute lymphoblastic leukemia (ALL) and 224 patients with acute myeloid leukemia (AML) up to 12 years old. The overall distribution of blood groups was significantly different in both ALL and AML groups from the control group (p < .001). In the ALL group there were 56.5% (95% CI: 45.8-67.1) more patients with O blood group, 35.8% (95% CI: 27.0-44.5) fewer patients with A blood group, and 26.9% (95% CI: 12.7-39.2) fewer patients with B blood group. In the AML group, there were 28.8% (95% CI: 10.8-46.9) more patients with A blood group. The results indicate that alteration in ABO antigens might be associated with an increased risk of ALL.
在一项多中心研究中，对682例12岁及以下的急性淋巴细胞白血病（ALL）患儿和224例急性髓细胞白血病（AML）患儿的ABO血型分布进行了测定。ALL组和AML组的血型总体分布与对照组均有显著差异（p <.001）。在ALL组中，O血型患者多56.5%（95%置信区间：45.8 - 67.1），A血型患者少35.8%（95%置信区间：27.0 - 44.5），B血型患者少26.9%（95%置信区间：12.7 - 39.2）。在AML组中，A血型患者多28.8%（95%置信区间：10.8 - 46.9）。结果表明，ABO抗原的改变可能与ALL风险增加有关。
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