Sorge Ina, Georgi Thomas Walter, Hirsch Franz Wolfgang
Institut für Kinderradiologie, Universitätsklinikum Leipzig, Liebigstraße 20a, 04103, Leipzig, Deutschland.
Klinik und Poliklinik für Nuklearmedizin, Universitätsklinikum Leipzig, Leipzig, Deutschland.
Radiologe. 2021 Jul;61(7):611-618. doi: 10.1007/s00117-021-00873-9. Epub 2021 Jun 23.
CLINICAL/METHODOLOGICAL ISSUE: Lymphoma is the third most common neoplasm in children. Detection, accurate staging, and restaging are important for all radiologists involved in the diagnosis of children.
Magnetic resonance imaging (MRI), positron emission tomography/computed tomography (PET/CT), CT, ultrasound, X‑ray.
Whole-body imaging (MRI and PET-MRI or PET-CT) play a key role in diagnostics and for therapy selection in Hodgkin lymphoma.
In particular, hybrid imaging using F‑FDG PET is proving to be a powerful method for staging and restaging.
Standardization of imaging and inclusion in therapy studies (e.g. within the framework of the EuroNet-PHL-C2 study) improves diagnostics and simultaneously reduces therapy-related side effects.
In Hodgkin lymphoma, deviations from the prescribed diagnostic procedure should be avoided. In clinically very heterogeneous non-Hodgkin lymphoma (NHL), on the other hand, the diagnostic procedure should be adapted to the actual clinical condition of the child. The role of interim PET in NHL is currently still the subject of clinical discussion.
临床/方法学问题：淋巴瘤是儿童中第三常见的肿瘤。对于所有参与儿童诊断的放射科医生来说，检测、准确分期及再分期都很重要。
磁共振成像（MRI）、正电子发射断层扫描/计算机断层扫描（PET/CT）、CT、超声、X射线。
全身成像（MRI以及PET-MRI或PET-CT）在霍奇金淋巴瘤的诊断及治疗选择中起关键作用。
特别是，使用F-FDG PET的混合成像被证明是一种强大的分期及再分期方法。
成像标准化并纳入治疗研究（如在EuroNet-PHL-C2研究框架内）可改善诊断，同时减少与治疗相关的副作用。
在霍奇金淋巴瘤中，应避免偏离规定的诊断程序。另一方面，在临床异质性很强的非霍奇金淋巴瘤（NHL）中，诊断程序应根据儿童的实际临床情况进行调整。 interim PET在NHL中的作用目前仍是临床讨论的主题。
