Kindblom Jenny M, Lorentzon Mattias, Norjavaara Ensio, Lönn Lars, Brandberg John, Angelhed Jan-Erik, Hellqvist Asa, Nilsson Staffan, Ohlsson Claes
Bone Research Center at the Institute of Medicine, Sahlgrenska Universitetssjukhuset/Sahlgrenska, Grona Straket 8, 413 45 Gothenburg, Sweden.
Diabetes. 2006 Nov;55(11):3047-52. doi: 10.2337/db06-0192.
The role of puberty and normal variations in pubertal timing for the development of obesity in men is unclear. The aim of the current study was to investigate the impact of pubertal timing and prepubertal BMI (kg/m(2)) for young adult BMI and fat mass distribution. Detailed growth charts from birth to age 18-20 years were retrieved for the men participating in the population-based Gothenburg Osteoporosis and Obesity Determinants study. Age at peak height velocity (PHV) and BMI at age 10 years were estimated for 579 subjects, and PHV was used as an assessment of pubertal timing. The fat mass characterization and distribution were analyzed using dual X-ray absorptiometry and peripheral as well as abdominal computed tomography at age 18.9 +/- 0.5 years. We demonstrate that age at PHV is an independent negative predictor of young adult BMI and whole-body fat mass. Interestingly, age at PHV is an independent negative predictor of central, but not peripheral, fat mass. In contrast, BMI at 10 years of age predicts both central and peripheral subcutaneous fat mass. In conclusion, we demonstrate that early pubertal onset specifically predicts a central fat mass distribution, while a predominantly subcutaneous obese phenotype is strongly predicted by a high prepubertal BMI.
青春期及青春期发育时间的正常变异在男性肥胖发展中的作用尚不清楚。本研究的目的是调查青春期发育时间和青春期前体重指数（kg/m²）对年轻成人的体重指数和脂肪量分布的影响。我们检索了参与基于人群的哥德堡骨质疏松症和肥胖决定因素研究的男性从出生到18 - 20岁的详细生长图表。对579名受试者估计了身高增长峰值速度（PHV）时的年龄和10岁时的体重指数，并将PHV用作青春期发育时间的评估指标。在18.9±0.5岁时，使用双能X线吸收法以及外周和腹部计算机断层扫描分析脂肪量特征和分布。我们证明，PHV时的年龄是年轻成人体重指数和全身脂肪量的独立负向预测因子。有趣的是，PHV时的年龄是中央脂肪量而非外周脂肪量的独立负向预测因子。相比之下，10岁时的体重指数可预测中央和外周皮下脂肪量。总之，我们证明青春期早发特别预示着中央脂肪量分布，而青春期前高体重指数则强烈预示着主要为皮下肥胖表型。
