Institute of Child and Adolescent Health, School of Public Health, Peking University, 100191, Beijing, China.
National Health Commission Key Laboratory of Reproductive Health, 100191, Beijing, China.
Eur J Clin Nutr. 2022 Oct;76(10):1432-1439. doi: 10.1038/s41430-022-01133-2. Epub 2022 May 6.
To assess the effects of prepubertal BMI on pubertal growth patterns, and the influence of prepubertal BMI and pubertal growth patterns on long-term BMI among Chinese children and adolescents.
A total of 9606 individuals aged between 7 and 18 years from longitudinal surveys in Zhongshan city of China from 2005 to 2016 were enrolled. Age at peak height velocity (APHV) and peak height velocity (PHV) were estimated using Super-Imposition by Translation and Rotation (SITAR) model. Associations between prepubertal BMI, APHV, PHV, and long-term overweight and obesity were assessed by linear regression and multinominal logistic regression. Scatter plots were elaborated to show the associations between prepubertal BMI and pubertal growth patterns according to prepubertal BMI categories.
Prepubertal BMI Z-Score was positively correlated with long-term BMI Z-Score, and negatively correlated with APHV in both sexes. In addition, there was a negative association between prepubertal BMI Z-Score and PHV in boys. With 1-year decrease in APHV, risk of long-term underweight decreased by 92%, while overweight increased by 33% in boys. Corresponding risk of long-term underweight and overweight for girls decreased by 42% and increased by 20%, respectively.
High prepubertal BMI levels were associated with earlier APHV and lower PHV, and the early onset of pubertal development could increase the risks of long-term overweight and obesity at 17-18 years of age both in boys and girls. Such evidence emphasized the importance of reducing prepubertal obesity risks combined with appropriate pubertal development timing, including later APHV and higher PHV, so as to prevent the obesity and related cardiovascular diseases in adulthood.
评估青春期前 BMI 对青春期生长模式的影响，以及青春期前 BMI 和青春期生长模式对中国儿童和青少年长期 BMI 的影响。
共纳入来自中国中山市 2005 年至 2016 年纵向调查的 9606 名 7 至 18 岁个体。使用平移旋转叠加（SITAR）模型估计年龄最大身高速度（APHV）和最大身高速度（PHV）。通过线性回归和多项逻辑回归评估青春期前 BMI、APHV、PHV 与长期超重和肥胖的相关性。根据青春期前 BMI 类别，绘制散点图以显示青春期前 BMI 与青春期生长模式之间的关联。
青春期前 BMI Z 评分与长期 BMI Z 评分呈正相关，与两性的 APHV 呈负相关。此外，男孩的青春期前 BMI Z 评分与 PHV 呈负相关。APHV 减少 1 年，男孩长期体重不足的风险降低 92%，超重风险增加 33%。女孩长期体重不足和超重的相应风险分别降低 42%和增加 20%。
较高的青春期前 BMI 水平与较早的 APHV 和较低的 PHV 相关，青春期发育的提前可能会增加男孩和女孩 17-18 岁时长期超重和肥胖的风险。这些证据强调了降低青春期前肥胖风险与适当的青春期发育时机相结合的重要性，包括较晚的 APHV 和较高的 PHV，以预防成年期的肥胖和相关心血管疾病。
