Bursa Jiri, Lebis Radek, Janicek Premysl
Institute of Solid Mechanics, Mechatronics and Biomechanics, Brno University of Technology, Technicka 2, 616 69, Brno, Czech Republic.
Technol Health Care. 2006;14(4-5):311-20.
The paper deals with problems related to computational modelling of stress-strain states in vascular smooth muscle cells (SMCs). First, motivation for stress-strain analysis of SMCs is presented. Problems of their structure, geometry, constitutive models and initial (stress-free) state are analyzed on the basis of anatomical, histological and physiological knowledge. Various types of computational FE models of SMCs are presented; their constitutive models are identified on the basis of published mechanical tests carried out with SMCs cultured in vitro. Results of two models are presented; the former is a homogeneous model of the cell tension test with hyperelastic constitutive relations of the cell material. The latter model is more complex, it comprehends cortical and deep cytoskeleton, modelled as a tensegrity structure, and homogeneous linear elastic nucleus and remaining cytoplasm; it is used in computational modelling of indentation test. Perspectives, assumptions and limitations of computational modelling of SMCs under physiological load are discussed.
本文探讨了与血管平滑肌细胞（SMC）应力应变状态计算建模相关的问题。首先，阐述了对SMC进行应力应变分析的动机。基于解剖学、组织学和生理学知识，分析了它们的结构、几何形状、本构模型和初始（无应力）状态问题。介绍了各种类型的SMC计算有限元模型；其本构模型是根据已发表的对体外培养的SMC进行的力学测试确定的。给出了两个模型的结果；前者是具有细胞材料超弹性本构关系的细胞张力测试均匀模型。后者模型更复杂，它包含皮质和深部细胞骨架，建模为张拉整体结构，以及均匀线性弹性细胞核和其余细胞质；它用于压痕测试的计算建模。讨论了在生理负荷下SMC计算建模的前景、假设和局限性。
