Kato M, Hirata S, Kikuchi A, Ogawa K, Kishimoto H, Hanada R
Division of Hematology/Oncology, Saitama Children's Medical Center, Saitama, Japan.
Pediatr Blood Cancer. 2008 Feb;50(2):391-2. doi: 10.1002/pbc.21065.
We report an infant with neuroblastoma who presented with dilated cardiomyopathy. A 3-month-old girl presented with dilated cardiomyopathy diagnosed as stage III neuroblastoma. Since total resection was impossible, chemotherapy was started. Cardiomyopathy was normalized by improvement of neuroblastoma. The prompt improvement of cardiac function following treatment of neuroblastoma suggested that cardiomyopathy in this patient was caused by the increase in catecholamines secreted by neuroblastoma and that reduction in catecholamines by treatment of neuroblastoma led to improvement in the cardiomyopathy.
我们报告了一名患有神经母细胞瘤并伴有扩张型心肌病的婴儿。一名3个月大的女孩被诊断为III期神经母细胞瘤并伴有扩张型心肌病。由于无法进行全切手术，遂开始化疗。随着神经母细胞瘤病情的改善，心肌病也恢复正常。神经母细胞瘤治疗后心脏功能迅速改善，这表明该患者的心肌病是由神经母细胞瘤分泌的儿茶酚胺增加所致，而神经母细胞瘤的治疗使儿茶酚胺减少，从而导致心肌病得到改善。
