Baylor College of Medicine, Houston, Texas, USA.
Pediatr Blood Cancer. 2010 Oct;55(4):736-8. doi: 10.1002/pbc.22569.
A 2-year-old African American male presented with heart failure and an abdominal mass. Computerized tomography (CT) scan revealed a 7 cm adrenal lesion, confirmed as poorly differentiated neuroblastoma (NB). CT and meta-iodobenzoguanidine (MIBG) scans identified multiple metastases, but cardiac MIBG imaging was absent. Cardiac ejection fraction (EF) was 8% with 7% shortening fraction. The patient underwent six cycles of chemotherapy and investigational immunotherapy. Cardiac function improved to 26% EF. However, the tumor proved unresponsive to treatment. The patient died from stage IV congestive heart failure (CHF) and progressive NB. Autopsy confirmed dilated cardiomyopathy with endocardial fibroelastosis.
一名 2 岁的非裔美国男性因心力衰竭和腹部肿块就诊。计算机断层扫描（CT）显示 7 厘米的肾上腺病变，被确认为低分化神经母细胞瘤（NB）。CT 和间碘苄胍（MIBG）扫描发现多处转移，但心脏 MIBG 成像缺失。心脏射血分数（EF）为 8%，缩短分数为 7%。患者接受了六轮化疗和试验性免疫治疗。心脏功能改善至 26%的 EF。然而，肿瘤对治疗无反应。患者死于 IV 期充血性心力衰竭（CHF）和进展性 NB。尸检证实为扩张型心肌病伴心内膜弹力纤维增生症。
