Furukawa S, Matsubara T, Jujoh K, Sasai K, Nakachi S, Sugawara T, Yabuta K, Kato H
Department of Paediatrics, Juntendo University School of Medicine, Tokyo, Japan.
Eur J Pediatr. 1990 Nov;150(1):43-7. doi: 10.1007/BF01959479.
The effects of intravenous gammaglobulin (IVGG) on changes in the peripheral blood mononuclear cell subsets during acute Kawasaki disease (KD) were studied by a random selection trial of IVGG plus Aspirin (group G) compared to Aspirin alone (group A). Group G received IVGG with 200 mg/kg per day x 5 dose. The absolute counts of peripheral blood mononuclear cell subsets were assayed by a fluorescence-activated cell sorter using monoclonal antibodies of Leu series. Before therapy, patients in each treatment group had increased counts of CD14 + macrophage/monocytes compared to healthy childhood controls (P less than 0.01). After IVGG treatment group G underwent a greater decrease in their CD14 + macrophage/monocyte counts (P less than 0.01) than group A. The changes of CD3+ T cells. Leu 7+ NK/K cells and CD19+ B cells in the peripheral blood mononuclear cell subsets with treatment in group G, were similar to those in group A. These results suggest the possibility that IVGG therapy is effective in KD by modulating macrophages/monocytes.
通过静脉注射丙种球蛋白（IVGG）加阿司匹林（G组）与单独使用阿司匹林（A组）的随机选择试验，研究了急性川崎病（KD）期间静脉注射丙种球蛋白对外周血单个核细胞亚群变化的影响。G组接受每天200mg/kg×5剂量的IVGG。使用Leu系列单克隆抗体，通过荧光激活细胞分选仪测定外周血单个核细胞亚群的绝对计数。治疗前，与健康儿童对照组相比，各治疗组患者的CD14 +巨噬细胞/单核细胞计数均增加（P<0.01）。IVGG治疗后，G组CD14 +巨噬细胞/单核细胞计数的下降幅度（P<0.01）大于A组。G组外周血单个核细胞亚群中CD3 + T细胞、Leu 7 + NK/K细胞和CD19 + B细胞随治疗的变化与A组相似。这些结果提示IVGG治疗可能通过调节巨噬细胞/单核细胞对KD有效。
