来自可可球二孢菌Menisporopsis theobromae BCC 3975的生物活性化合物。

Bioactive compounds from the seed fungus Menisporopsis theobromae BCC 3975.

作者信息

Chinworrungsee Maneekarn, Kittakoop Prasat, Saenboonrueng Janya, Kongsaeree Palangpon, Thebtaranonth Yodhathai

机构信息

Department of Chemistry, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.

出版信息

J Nat Prod. 2006 Oct;69(10):1404-10. doi: 10.1021/np0601197.

DOI:10.1021/np0601197

PMID:17067151

Abstract

Eight new compounds (2-9), together with a known dithiodiketopiperazine (1), were isolated from the seed fungus Menisporopsis theobromae BCC 3975. The structures of these substances were elucidated by analyses of spectroscopic data. Compounds 1 and 4 exhibited moderate cytotoxicity against BC-1 cell lines with IC50 values of 29.2 and 57.4 microM, respectively. Cytotoxicity of 1, 2, 4, and 9 against the NCI-H187 cell line showed respective IC50 values of 22.9, 20.3, 1.8, and 56.6 microM. Compounds 2 and 4 exhibited antimalarial activity with IC50 values of 2.95 and 28.8 microM, respectively. Substances 1, 4, 7, 8, and 9 possessed weak antimycobacterial activity (MIC 154.8-952.3 microM), while compounds 2 and 3 showed potent antimycobacterial activity with respective MIC values of 1.24 and 7.14 microM.

摘要

从可可拟盘多毛孢菌Menisporopsis theobromae BCC 3975的种子真菌中分离出8种新化合物（2 - 9）以及一种已知的二硫代二酮哌嗪（1）。通过光谱数据分析阐明了这些物质的结构。化合物1和4对BC - 1细胞系表现出中等细胞毒性，IC50值分别为29.2和57.4微摩尔。1、2、4和9对NCI - H187细胞系的细胞毒性显示IC50值分别为22.9、20.3、1.8和56.6微摩尔。化合物2和4表现出抗疟活性，IC50值分别为2.95和28.8微摩尔。物质1、4、7、8和9具有较弱的抗分枝杆菌活性（MIC为154.8 - 952.3微摩尔），而化合物2和3表现出较强的抗分枝杆菌活性，MIC值分别为1.24和7.14微摩尔。