来自巴西毛壳菌的抗疟和细胞毒性缩酚酸环醚

Antimalarial and cytotoxic depsidones from the fungus Chaetomium brasiliense.

作者信息

Khumkomkhet Primmala, Kanokmedhakul Somdej, Kanokmedhakul Kwanjai, Hahnvajanawong Chariya, Soytong Kasem

机构信息

Natural Products Research Unit, Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand.

出版信息

J Nat Prod. 2009 Aug;72(8):1487-91. doi: 10.1021/np9003189.

DOI:10.1021/np9003189

PMID:19663417

Abstract

Four new depsidones, mollicellins K-N (1-4), and six known depsidones, mollicellins B (5), C (6), E (7), F (8), H (9), and J (10), along with two known sterols were isolated from the fungus Chaetomium brasiliense. Their structures were elucidated on the basis of 1D and 2D NMR spectroscopic data and chemical transformation. Among these isolates, 1-3, 5-7, and 10 exhibited antimalarial activity against Plasmodium falciparum. Only 1 exhibited antimycobacterial activity against Mycobacterium tuberculosis and antifungal activity against Candida albicans using in vitro assays. In addition, 1-10 showed cytotoxicity against the KB, BC1, NCI-H187, and five cholangiocarcinoma cell lines.

摘要

从巴西毛壳菌中分离出4个新的缩酚酸酮类化合物，即毛壳菌素K-N（1-4），以及6个已知的缩酚酸酮类化合物，毛壳菌素B（5）、C（6）、E（7）、F（8）、H（9）和J（10），同时还分离出2个已知的甾醇类化合物。通过一维和二维核磁共振光谱数据以及化学转化对它们的结构进行了阐明。在这些分离物中，1-3、5-7和10对恶性疟原虫表现出抗疟活性。在体外试验中，只有1对结核分枝杆菌表现出抗分枝杆菌活性，对白色念珠菌表现出抗真菌活性。此外，1-10对KB、BC1、NCI-H187和5种胆管癌细胞系显示出细胞毒性。