来自亚肉座菌的细胞毒性下霉素类似物。
Cytotoxic hypothemycin analogues from Hypomyces subiculosus.
作者信息
Wee Janice L, Sundermann Kurt, Licari Peter, Galazzo Jorge
机构信息
Kosan Biosciences, Inc., Hayward, California 94545, USA.
出版信息
J Nat Prod. 2006 Oct;69(10):1456-9. doi: 10.1021/np060258o.
PMID:17067161
Abstract
Three new hypothemycin analogues were isolated from the fungal strains Hypomyces subiculosus DSM 11931 and DSM 11932. The structures of these compounds were elucidated by spectroscopic methods, chemical conversion, and X-ray crystallographic analysis. One of the analogues, 4-O-demethylhypothemycin, exhibited potent and selective cytotoxic activity against cell lines with a BRAF mutation.
摘要
从真菌菌株肉座菌DSM 11931和DSM 11932中分离出三种新的腐霉素类似物。通过光谱方法、化学转化和X射线晶体学分析阐明了这些化合物的结构。其中一种类似物4-O-去甲基腐霉素对具有BRAF突变的细胞系表现出强效且选择性的细胞毒性活性。
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