Key Laboratory of Systematic Mycology & Lichenology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, People's Republic of China.
J Nat Prod. 2009 Dec;72(12):2184-7. doi: 10.1021/np900619z.
The new pyrrolidinones, rigidiusculamides A-D (1-4), have been isolated from the crude extract of the ascomycete fungus Albonectria rigidiuscula. The structures of these compounds were elucidated primarily by NMR experiments. The absolute configuration of the 3,4-diol moieties in 1 and 4 was assigned using Snatzke's method. Compounds 1 and 2 showed modest cytotoxicity against the human tumor cell lines HeLa and MCF-7.
新的吡咯烷酮类化合物，rigidiusculamides A-D（1-4），从子囊菌真菌 Albonectria rigidiuscula 的粗提物中分离得到。这些化合物的结构主要通过 NMR 实验阐明。使用 Snatzke 法确定了 1 和 4 中 3,4-二醇部分的绝对构型。化合物 1 和 2 对人肿瘤细胞系 HeLa 和 MCF-7 表现出适度的细胞毒性。
