高Smac/DIABLO表达与宫颈癌早期局部复发相关。

High Smac/DIABLO expression is associated with early local recurrence of cervical cancer.

作者信息

Arellano-Llamas Abril, Garcia Francisco J, Perez Delia, Cantu David, Espinosa Magali, De la Garza Jaime G, Maldonado Vilma, Melendez-Zajgla Jorge

机构信息

Subdirección de Investigación Básica, Instituto Nacional de Cancerología, Av, San Fernando # 22, Tlalpan 14080 México City, Mexico.

出版信息

BMC Cancer. 2006 Oct 26;6:256. doi: 10.1186/1471-2407-6-256.

BACKGROUND

In a recent pilot report, we showed that Smac/DIABLO mRNA is expressed de novo in a subset of cervical cancer patients. We have now expanded this study and analyzed Smac/DIABLO expression in the primary lesions in 109 cervical cancer patients.

METHODS

We used immunohistochemistry of formalin-fixed, paraffin-embedded tissue sections to analyze Smac/DIABLO expression in the 109 primary lesions. Seventy-eight samples corresponded to epidermoid cervical cancer and 31 to cervical adenocarcinoma. The median follow up was 46.86 months (range 10-186).

RESULTS

Smac/DIABLO was expressed in more adenocarcinoma samples than squamous tumours (71% vs 50%; p = 0.037). Among the pathological variables, a positive correlation was found between Smac/DIABLO immunoreactivity and microvascular density, a marker for angiogenesis (p = 0.04). Most importantly, Smac/DIABLO immunoreactivity was associated with a higher rate of local recurrence in squamous cell carcinoma (p = 0.002, log rank test). No association was found between Smac/DIABLO and survival rates.

CONCLUSION

Smac/DIABLO expression is a potential marker for local recurrence in cervical squamous cell carcinoma patients.

背景

在最近一份初步报告中，我们显示Smac/DIABLO信使核糖核酸在部分宫颈癌患者中重新表达。我们现在扩大了这项研究，并分析了109例宫颈癌患者原发灶中Smac/DIABLO的表达情况。

方法

我们使用福尔马林固定、石蜡包埋组织切片的免疫组织化学方法，分析109例原发灶中Smac/DIABLO的表达。78个样本为宫颈鳞状细胞癌，31个样本为宫颈腺癌。中位随访时间为46.86个月（范围10 - 186个月）。

结果

Smac/DIABLO在腺癌样本中的表达多于鳞状肿瘤（71%对50%；p = 0.037）。在病理变量中，发现Smac/DIABLO免疫反应性与微血管密度（一种血管生成标志物）之间存在正相关（p = 0.04）。最重要的是，Smac/DIABLO免疫反应性与鳞状细胞癌的局部复发率较高相关（p = 0.002，对数秩检验）。未发现Smac/DIABLO与生存率之间存在关联。