• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

高Smac/DIABLO表达与宫颈癌早期局部复发相关。

High Smac/DIABLO expression is associated with early local recurrence of cervical cancer.

作者信息

Arellano-Llamas Abril, Garcia Francisco J, Perez Delia, Cantu David, Espinosa Magali, De la Garza Jaime G, Maldonado Vilma, Melendez-Zajgla Jorge

机构信息

Subdirección de Investigación Básica, Instituto Nacional de Cancerología, Av, San Fernando # 22, Tlalpan 14080 México City, Mexico.

出版信息

BMC Cancer. 2006 Oct 26;6:256. doi: 10.1186/1471-2407-6-256.

DOI:10.1186/1471-2407-6-256
PMID:17067390
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3225885/
Abstract

BACKGROUND

In a recent pilot report, we showed that Smac/DIABLO mRNA is expressed de novo in a subset of cervical cancer patients. We have now expanded this study and analyzed Smac/DIABLO expression in the primary lesions in 109 cervical cancer patients.

METHODS

We used immunohistochemistry of formalin-fixed, paraffin-embedded tissue sections to analyze Smac/DIABLO expression in the 109 primary lesions. Seventy-eight samples corresponded to epidermoid cervical cancer and 31 to cervical adenocarcinoma. The median follow up was 46.86 months (range 10-186).

RESULTS

Smac/DIABLO was expressed in more adenocarcinoma samples than squamous tumours (71% vs 50%; p = 0.037). Among the pathological variables, a positive correlation was found between Smac/DIABLO immunoreactivity and microvascular density, a marker for angiogenesis (p = 0.04). Most importantly, Smac/DIABLO immunoreactivity was associated with a higher rate of local recurrence in squamous cell carcinoma (p = 0.002, log rank test). No association was found between Smac/DIABLO and survival rates.

CONCLUSION

Smac/DIABLO expression is a potential marker for local recurrence in cervical squamous cell carcinoma patients.

摘要

背景

在最近一份初步报告中，我们显示Smac/DIABLO信使核糖核酸在部分宫颈癌患者中重新表达。我们现在扩大了这项研究，并分析了109例宫颈癌患者原发灶中Smac/DIABLO的表达情况。

方法

我们使用福尔马林固定、石蜡包埋组织切片的免疫组织化学方法，分析109例原发灶中Smac/DIABLO的表达。78个样本为宫颈鳞状细胞癌，31个样本为宫颈腺癌。中位随访时间为46.86个月（范围10 - 186个月）。

结果

Smac/DIABLO在腺癌样本中的表达多于鳞状肿瘤（71%对50%；p = 0.037）。在病理变量中，发现Smac/DIABLO免疫反应性与微血管密度（一种血管生成标志物）之间存在正相关（p = 0.04）。最重要的是，Smac/DIABLO免疫反应性与鳞状细胞癌的局部复发率较高相关（p = 0.002，对数秩检验）。未发现Smac/DIABLO与生存率之间存在关联。

结论

Smac/DIABLO表达是宫颈鳞状细胞癌患者局部复发的一个潜在标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd3a/3225885/33fb6f3864d6/1471-2407-6-256-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd3a/3225885/09b16cf8865a/1471-2407-6-256-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd3a/3225885/5adc6c5c7ae2/1471-2407-6-256-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd3a/3225885/de266efc0caf/1471-2407-6-256-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd3a/3225885/e379f0cae19c/1471-2407-6-256-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd3a/3225885/33fb6f3864d6/1471-2407-6-256-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd3a/3225885/09b16cf8865a/1471-2407-6-256-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd3a/3225885/5adc6c5c7ae2/1471-2407-6-256-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd3a/3225885/de266efc0caf/1471-2407-6-256-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd3a/3225885/e379f0cae19c/1471-2407-6-256-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd3a/3225885/33fb6f3864d6/1471-2407-6-256-5.jpg

相似文献

1
High Smac/DIABLO expression is associated with early local recurrence of cervical cancer.高Smac/DIABLO表达与宫颈癌早期局部复发相关。
BMC Cancer. 2006 Oct 26;6:256. doi: 10.1186/1471-2407-6-256.
2
Clinical significance of Smac/DIABLO expression in colorectal cancer.Smac/DIABLO表达在结直肠癌中的临床意义
Oncol Rep. 2009 Feb;21(2):351-5.
3
Downregulation of Smac/DIABLO expression in renal cell carcinoma and its prognostic significance.肾细胞癌中Smac/DIABLO表达下调及其预后意义
J Clin Oncol. 2005 Jan 20;23(3):448-54. doi: 10.1200/JCO.2005.02.191. Epub 2004 Nov 30.
4
Immunoexpression of DIABLO, AIF and cytochrome C in gastric adenocarcinoma assessed by tissue Microarray.应用组织微阵列技术检测胃腺癌中 DIABLO、AIF 和细胞色素 C 的免疫表达。
Anticancer Res. 2013 Feb;33(2):647-53.
5
SMAC is expressed de novo in a subset of cervical cancer tumors.凋亡小体相关分子（SMAC）在一部分宫颈癌肿瘤中重新表达。
BMC Cancer. 2004 Nov 23;4:84. doi: 10.1186/1471-2407-4-84.
6
Disturbed expression of the apoptosis regulators XIAP, XAF1, and Smac/DIABLO in gastric adenocarcinomas.凋亡调节因子XIAP、XAF1和Smac/DIABLO在胃腺癌中的表达失调。
Diagn Mol Pathol. 2007 Mar;16(1):1-8. doi: 10.1097/01.pdm.0000213471.92925.51.
7
Influence of high expression of Smac/DIABLO protein on the clinical outcome in acute myeloid leukemia patients.Smac/DIABLO 蛋白高表达对急性髓系白血病患者临床结局的影响。
Leuk Res. 2010 Oct;34(10):1308-13. doi: 10.1016/j.leukres.2009.11.030. Epub 2010 Jan 12.
8
Galectin-1 is an independent prognostic factor for local recurrence and survival after definitive radiation therapy for patients with squamous cell carcinoma of the uterine cervix.半乳糖凝集素-1 是子宫颈鳞状细胞癌患者接受根治性放疗后局部复发和生存的独立预后因素。
Int J Radiat Oncol Biol Phys. 2013 Dec 1;87(5):975-82. doi: 10.1016/j.ijrobp.2013.08.037. Epub 2013 Oct 16.
9
LRIG2 in contrast to LRIG1 predicts poor survival in early-stage squamous cell carcinoma of the uterine cervix.LRIG2 与 LRIG1 相反，可预测早期子宫颈鳞状细胞癌的不良预后。
Acta Oncol. 2010 Aug;49(6):812-5. doi: 10.3109/0284186X.2010.492789.
10
Immunoexpression of inhibitors of apoptosis proteins and their antagonist SMAC/DIABLO in colorectal carcinoma: correlation with apoptotic index, cellular proliferation and prognosis.凋亡抑制蛋白及其拮抗剂SMAC/DIABLO在结直肠癌中的免疫表达：与凋亡指数、细胞增殖及预后的相关性
Oncol Rep. 2009 Aug;22(2):295-303.

引用本文的文献

1
Potency and Selectivity of SMAC/DIABLO Mimetics in Solid Tumor Therapy.SMAC/DIABLO 模拟物在实体瘤治疗中的效力和选择性。
Cells. 2020 Apr 18;9(4):1012. doi: 10.3390/cells9041012.
2
Low expression of pro-apoptotic proteins Bax, Bak and Smac indicates prolonged progression-free survival in chemotherapy-treated metastatic melanoma.促凋亡蛋白 Bax、Bak 和 Smac 表达水平低表明化疗治疗转移性黑色素瘤患者无进展生存期延长。
Cell Death Dis. 2020 Feb 13;11(2):124. doi: 10.1038/s41419-020-2309-3.
3
Genomics of a pediatric ovarian fibrosarcoma. Association with the DICER1 syndrome.

本文引用的文献

1
TRAIL resistance results in cancer progression: a TRAIL to perdition?TRAIL抗性导致癌症进展：走向毁灭之路？
Oncogene. 2006 Nov 30;25(56):7333-5. doi: 10.1038/sj.onc.1209765. Epub 2006 Jun 19.
2
Inhibitors of apoptosis proteins in human cervical cancer.人类宫颈癌中的凋亡抑制蛋白
BMC Cancer. 2006 Feb 27;6:45. doi: 10.1186/1471-2407-6-45.
3
Increased expression of apoptosis inhibitor protein XIAP contributes to anoikis resistance of circulating human prostate cancer metastasis precursor cells.凋亡抑制蛋白XIAP的表达增加有助于循环中的人前列腺癌转移前体细胞的失巢凋亡抗性。
儿童卵巢纤维肉瘤的基因组学。与 DICER1 综合征相关。
Sci Rep. 2018 Feb 19;8(1):3252. doi: 10.1038/s41598-018-21663-9.
4
A New Role for the Mitochondrial Pro-apoptotic Protein SMAC/Diablo in Phospholipid Synthesis Associated with Tumorigenesis.线粒体促凋亡蛋白 SMAC/Diablo 在与肿瘤发生相关的磷脂合成中的新作用。
Mol Ther. 2018 Mar 7;26(3):680-694. doi: 10.1016/j.ymthe.2017.12.020. Epub 2017 Dec 24.
5
Angiogenesis and evading immune destruction are the main related transcriptomic characteristics to the invasive process of oral tongue cancer.血管生成和逃避免疫破坏是口腔舌癌侵袭过程中主要相关的转录组学特征。
Sci Rep. 2018 Jan 31;8(1):2007. doi: 10.1038/s41598-017-19010-5.
6
A molecular signature of lung cancer: potential biomarkers for adenocarcinoma and squamous cell carcinoma.肺癌的分子特征：腺癌和鳞状细胞癌的潜在生物标志物。
Oncotarget. 2017 Nov 6;8(62):105492-105509. doi: 10.18632/oncotarget.22298. eCollection 2017 Dec 1.
7
XIAP inhibits mature Smac-induced apoptosis by degrading it through ubiquitination in NSCLC.在非小细胞肺癌中，XIAP通过泛素化降解成熟的Smac，从而抑制其诱导的细胞凋亡。
Int J Oncol. 2016 Oct;49(4):1289-96. doi: 10.3892/ijo.2016.3634. Epub 2016 Jul 27.
8
Novel Biomarker Proteins in Chronic Lymphocytic Leukemia: Impact on Diagnosis, Prognosis and Treatment.慢性淋巴细胞白血病中的新型生物标志物蛋白：对诊断、预后和治疗的影响
PLoS One. 2016 Apr 14;11(4):e0148500. doi: 10.1371/journal.pone.0148500. eCollection 2016.
9
Effect of Smac in combination with cisplatin on esophageal cancer cell line ECA109.Smac与顺铂联合应用对食管癌细胞系ECA109的影响。
Int J Clin Exp Med. 2015 Oct 15;8(10):18506-11. eCollection 2015.
10
IAP proteins as targets for drug development in oncology.IAP蛋白作为肿瘤学药物开发的靶点。
Onco Targets Ther. 2013 Sep 16;9:1285-304. doi: 10.2147/OTT.S33375.
Cancer Res. 2005 Mar 15;65(6):2378-86. doi: 10.1158/0008-5472.CAN-04-2649.
4
X-linked inhibitor of apoptosis functions as ubiquitin ligase toward mature caspase-9 and cytosolic Smac/DIABLO.X连锁凋亡抑制蛋白作为一种泛素连接酶作用于成熟的半胱天冬酶-9和胞质中的Smac/DIABLO。
J Biochem. 2005 Feb;137(2):125-32. doi: 10.1093/jb/mvi029.
5
Downregulation of Smac/DIABLO expression in renal cell carcinoma and its prognostic significance.肾细胞癌中Smac/DIABLO表达下调及其预后意义
J Clin Oncol. 2005 Jan 20;23(3):448-54. doi: 10.1200/JCO.2005.02.191. Epub 2004 Nov 30.
6
SMAC is expressed de novo in a subset of cervical cancer tumors.凋亡小体相关分子（SMAC）在一部分宫颈癌肿瘤中重新表达。
BMC Cancer. 2004 Nov 23;4:84. doi: 10.1186/1471-2407-4-84.
7
Inhibitor of apoptosis proteins: translating basic knowledge into clinical practice.凋亡抑制蛋白：将基础知识转化为临床实践
Cancer Res. 2004 Oct 15;64(20):7183-90. doi: 10.1158/0008-5472.CAN-04-1918.
8
The inhibitor of apoptosis protein family (IAPs): an emerging therapeutic target in cancer.凋亡抑制蛋白家族（IAPs）：癌症中一个新兴的治疗靶点。
Semin Cancer Biol. 2004 Aug;14(4):231-43. doi: 10.1016/j.semcancer.2004.04.002.
9
Direct interaction of Smac with NADE promotes TRAIL-induced apoptosis.Smac与NADE的直接相互作用促进肿瘤坏死因子相关凋亡诱导配体（TRAIL）诱导的细胞凋亡。
Biochem Biophys Res Commun. 2004 Jun 25;319(2):649-54. doi: 10.1016/j.bbrc.2004.05.043.
10
Expression of Smac/DIABLO is a novel prognostic marker in lung cancer.Smac/DIABLO的表达是肺癌中一种新的预后标志物。
Oncol Rep. 2004 Apr;11(4):797-802.