Association of chemokine receptor 5 (CCR5) delta32 mutation with Behçet's disease is dependent on gender in Iranian patients.

OBJECTIVE

Behçet's disease (BD) is a recurrent multi-system inflammatory disorder caused by the combinations of multiple genetic and environmental factors. CCR5 is a Th1-dominant chemokine receptor whose levels are increased in patients with active BD. It is believed that a 32 bp deletion in the CCR5 gene reduces the expression of this receptor on the cell surface. The aim of the present study was to investigate the association of CCR5 delta32 allele with BD in Iranian patients.

METHODS

The study included 100 patients with BD and 380 healthy controls. Polymerase chain reaction (PCR) amplification was used for analysis of CCR5 delta32 allele.

RESULTS

The frequency of CCR5 delta32 allele was not statistically different between 100 patients with BD and 380 healthy individuals. However, categorizing patients according to gender revealed a significant difference in distribution of the CCR5 delta32 allele in female patients compared with female control individuals (p = 0.047, fisher's exact test, OR = 2.66).

CONCLUSION

The results suggest that the CCR5 delta32 allele may be a genetic risk factor for BD in Iranian women. These results warrant further investigation to clarify the underlying mechanism of CCR5 deficiency in the initiation of BD.