Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
State Key Laboratory of Complex, Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
Front Immunol. 2023 Jan 18;14:1109147. doi: 10.3389/fimmu.2023.1109147. eCollection 2023.
Behçet's disease (BD), a chronic vascular inflammatory disease, is characterized by the symptoms of ocular lesions, recurrent genital and oral ulcers, skin symptoms and arthritis in addition to neurological, intestinal and vascular involvement. The pathogenesis of BD is poorly understood, and there are no effective laboratory markers for the diagnosis of BD. In addition, BD is presently incurable. Chemokines, a family of small secreted chemotactic cytokines, interact with chemokine receptors and mediate the migration, localization and cellular interactions of inflammatory cells. Several studies have suggested that chemokines and their receptors play an important role in the occurrence and development of BD and that these chemokines along with their receptors can be utilized as biomarkers and therapeutic targets. In the present review, chemokines and chemokine receptors involved in BD and their potential application in diagnosis and therapy have been discussed.
贝赫切特病（BD）是一种慢性血管炎症性疾病，除了神经、肠道和血管受累外，其特征还包括眼部病变、复发性生殖器和口腔溃疡、皮肤症状和关节炎。BD 的发病机制尚不清楚，也没有用于 BD 诊断的有效实验室标志物。此外，BD 目前无法治愈。趋化因子是一小类分泌趋化细胞因子，与趋化因子受体相互作用并介导炎症细胞的迁移、定位和细胞相互作用。多项研究表明，趋化因子及其受体在 BD 的发生发展中起着重要作用，这些趋化因子及其受体可以作为生物标志物和治疗靶点。在本综述中，讨论了参与 BD 的趋化因子和趋化因子受体及其在诊断和治疗中的潜在应用。
