基质金属蛋白酶及其组织抑制剂在口腔扁平苔藓中的作用
[The role of matrix metalloproteinases and their tissue inhibitors in oral lichen planus].
作者信息
Zhang Wei-ping, Chen Yu, Geng Ning, Tian Kun, Bao Dong-mei, Yang Ming-zhong
机构信息
Department of Oral Pathology, West China School of Stomatology, Sichuan University, Chengdu 610041, China.
出版信息
Zhonghua Kou Qiang Yi Xue Za Zhi. 2006 Jul;41(7):420-1.
OBJECTIVE
To investigate the role of MMP-2, MT1-MMP and TIMP-2 in the carcinogenesis of oral lichen planus (OLP).
METHODS
Immunohistochemistry was performed to examine the expression of OLP and compare with that of NOM.
RESULTS
The expression of these proteinases significantly increased from NOM, non-atrophic OLP, to atrophic OLP and OSCC. The expression of MMP-2 and MT1-MMP in atrophic OLP was significantly higher than in non-atrophic OLP. Furthermore, the expression of TIMP-2 consequently increased with the increasing of the MMP, but the increase of TIMP-2 was less than that of MMP.
CONCLUSIONS
MMP may be useful marker to judge the possibility of malignant change of OLP.
目的
探讨基质金属蛋白酶-2（MMP-2）、膜型基质金属蛋白酶-1（MT1-MMP）和基质金属蛋白酶组织抑制因子-2（TIMP-2）在口腔扁平苔藓（OLP）癌变中的作用。
方法
采用免疫组织化学法检测OLP的表达，并与正常口腔黏膜（NOM）进行比较。
结果
从NOM、非萎缩性OLP到萎缩性OLP及口腔鳞状细胞癌（OSCC），这些蛋白酶的表达显著增加。萎缩性OLP中MMP-2和MT1-MMP的表达明显高于非萎缩性OLP。此外，TIMP-2的表达随MMP的增加而增加，但TIMP-2的增加幅度小于MMP。
结论
MMP可能是判断OLP恶变可能性的有用标志物。
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