Lassoued Slim, Zabraniecki Laurent, Marin Frédéric, Billey Thierry
Service de Rhumatologie, Centre Hospitalier, Cahors, France.
Semin Arthritis Rheum. 2007 Feb;36(4):262-3. doi: 10.1016/j.semarthrit.2006.08.004. Epub 2006 Oct 25.
To present the data supporting the possible relationship of ocular toxoplasmosis to antitumor necrosis factor-alpha (TNF-alpha) therapy in patients with rheumatoid arthritis (RA).
A Medline search was performed using the words "toxoplasmosis, anti-TNF-alpha antagonists, chorioretinitis." We report 2 RA patients who developed ocular toxoplasmosis while receiving anti-TNF-alpha therapy.
In addition to our patients with toxoplasmic chorioretinitis, there are 2 published cases of cerebral toxoplasmosis during treatment with anti-TNF-alpha agents.
The risk of serious toxoplasmic infection during anti-TNF-alpha therapy for RA should be recognized.
提供数据支持眼部弓形虫病与类风湿关节炎（RA）患者抗肿瘤坏死因子-α（TNF-α）治疗之间可能存在的关系。
使用“弓形虫病、抗TNF-α拮抗剂、脉络膜视网膜炎”等词在医学文献数据库（Medline）中进行检索。我们报告了2例类风湿关节炎患者在接受抗TNF-α治疗期间发生眼部弓形虫病的病例。
除了我们患有弓形虫性脉络膜视网膜炎的患者外，还有2例已发表的在用抗TNF-α药物治疗期间发生脑弓形虫病的病例。
应认识到类风湿关节炎患者接受抗TNF-α治疗期间发生严重弓形虫感染的风险。
