类风湿关节炎中的弓形虫性脉络膜视网膜炎与抗肿瘤坏死因子治疗
Toxoplasmic chorioretinitis and antitumor necrosis factor treatment in rheumatoid arthritis.
作者信息
Lassoued Slim, Zabraniecki Laurent, Marin Frédéric, Billey Thierry
机构信息
Service de Rhumatologie, Centre Hospitalier, Cahors, France.
出版信息
Semin Arthritis Rheum. 2007 Feb;36(4):262-3. doi: 10.1016/j.semarthrit.2006.08.004. Epub 2006 Oct 25.
OBJECTIVES
To present the data supporting the possible relationship of ocular toxoplasmosis to antitumor necrosis factor-alpha (TNF-alpha) therapy in patients with rheumatoid arthritis (RA).
METHODS
A Medline search was performed using the words "toxoplasmosis, anti-TNF-alpha antagonists, chorioretinitis." We report 2 RA patients who developed ocular toxoplasmosis while receiving anti-TNF-alpha therapy.
RESULTS
In addition to our patients with toxoplasmic chorioretinitis, there are 2 published cases of cerebral toxoplasmosis during treatment with anti-TNF-alpha agents.
CONCLUSION
The risk of serious toxoplasmic infection during anti-TNF-alpha therapy for RA should be recognized.
目的
提供数据支持眼部弓形虫病与类风湿关节炎（RA）患者抗肿瘤坏死因子-α（TNF-α）治疗之间可能存在的关系。
方法
使用“弓形虫病、抗TNF-α拮抗剂、脉络膜视网膜炎”等词在医学文献数据库（Medline）中进行检索。我们报告了2例类风湿关节炎患者在接受抗TNF-α治疗期间发生眼部弓形虫病的病例。
结果
除了我们患有弓形虫性脉络膜视网膜炎的患者外，还有2例已发表的在用抗TNF-α药物治疗期间发生脑弓形虫病的病例。
结论
应认识到类风湿关节炎患者接受抗TNF-α治疗期间发生严重弓形虫感染的风险。
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