Salem Doaa A, Al-Ghamdi Ahmed Hassan, Alghamdi Jameel Mohamed, Ismail Amira, Alghamdi Bakheet A, Abdelrazek Eman
Department of Medical Parasitology, Mansoura University, Faculty of Medicine, Egypt.
Department of Pediatrics; Al Baha University, Faculty of Medicine, Saudi Arabia.
Food Waterborne Parasitol. 2023 May 19;31:e00195. doi: 10.1016/j.fawpar.2023.e00195. eCollection 2023 Jun.
Juvenile idiopathic arthritis (JIA) is the most frequently encountered autoimmune rheumatic disease in children. To our knowledge, this is the first study aimed to estimate the frequency of ( and seropositivity in JIA and assess its relation to the disease activity, IL-10 levels, and type of the received therapies. This study was conducted on 43 JIA patients and 50 cases as a control group. All participants were evaluated by disease activity score (JADAS-27), and the presence of specific IgG and IgM antibodies against IgG against species using an enzyme-linked immunosorbent assay. IL-10 serum levels were measured using an ELISA kit. The results show that JIA patients have significantly higher seropositivity for anti- IgG compared to control subjects ( = 0.02) and a non-significant difference for seropositivity ( = 0.41). All participants were negative for IgM anti-. Demographic parameters did not significantly affect these seroprevalence frequencies ( > 0.05). IL-10 was significantly higher among JIA patients compared to controls ( = 0.007) and seropositive anti- JIA exhibited significantly higher IL-10 levels compared to seronegative ones ( = 0.03). Seropositive anti- IgG JIA patients had a significantly higher disease activity score (JADAS-27) than seronegative anti- IgG cases ( = 0.02). There was a significant positive correlation between anti- IgG and JADAS-27 score ( = 0.009). A significant association was detected between infection and DMARDs including the biological therapies ( < 0.05). Overall, this study supports a possible association between infection and JIA, IL-10, disease activity score, and DMARDs therapies. It is possible that IL-10 plays a role in the development of JIA and contributes to persistent asymptomatic infection with in JIA patients. As a result, a recommendation for screening tests for infection among JIA patients is crucial before and during commencing DMARDs therapies and closely monitoring early signs of infection.
幼年特发性关节炎（JIA）是儿童中最常见的自身免疫性风湿性疾病。据我们所知，这是第一项旨在评估JIA中（此处原文缺失具体内容）和（此处原文缺失具体内容）血清阳性率，并评估其与疾病活动度、白细胞介素-10（IL-10）水平及所接受治疗类型之间关系的研究。本研究对43例JIA患者和50例作为对照组的病例进行。所有参与者均通过疾病活动评分（JADAS-27）进行评估，并使用酶联免疫吸附测定法检测针对（此处原文缺失具体内容）的特异性IgG和IgM抗体以及针对（此处原文缺失具体内容）物种的IgG抗体的存在情况。使用ELISA试剂盒测量IL-10血清水平。结果显示，与对照组相比，JIA患者抗（此处原文缺失具体内容）IgG的血清阳性率显著更高（P = 0.02），而（此处原文缺失具体内容）血清阳性率无显著差异（P = 0.41）。所有参与者抗（此处原文缺失具体内容）IgM均为阴性。人口统计学参数对这些血清流行率无显著影响（P > 0.05）。与对照组相比，JIA患者中的IL-10显著更高（P = 0.007），抗（此处原文缺失具体内容）血清阳性的JIA患者的IL-10水平显著高于血清阴性患者（P = 0.03）。抗（此处原文缺失具体内容）IgG血清阳性的JIA患者的疾病活动评分（JADAS-27）显著高于抗（此处原文缺失具体内容）IgG血清阴性的病例（P = 0.02）。抗（此处原文缺失具体内容）IgG与JADAS-27评分之间存在显著正相关（P = 0.009）。在（此处原文缺失具体内容）感染与包括生物疗法在内的改善病情抗风湿药（DMARDs）之间检测到显著关联（P < 0.05）。总体而言，本研究支持（此处原文缺失具体内容）感染与JIA、IL-10、疾病活动评分及DMARDs治疗之间可能存在关联。IL-10可能在JIA的发展中起作用，并导致JIA患者持续无症状的（此处原文缺失具体内容）感染。因此，在开始DMARDs治疗之前和期间对JIA患者进行（此处原文缺失具体内容）感染筛查测试并密切监测感染早期迹象的建议至关重要。
