and seropositivity in juvenile idiopathic arthritis and its relation to disease activity and type of therapies.

Juvenile idiopathic arthritis (JIA) is the most frequently encountered autoimmune rheumatic disease in children. To our knowledge, this is the first study aimed to estimate the frequency of ( and seropositivity in JIA and assess its relation to the disease activity, IL-10 levels, and type of the received therapies. This study was conducted on 43 JIA patients and 50 cases as a control group. All participants were evaluated by disease activity score (JADAS-27), and the presence of specific IgG and IgM antibodies against IgG against species using an enzyme-linked immunosorbent assay. IL-10 serum levels were measured using an ELISA kit. The results show that JIA patients have significantly higher seropositivity for anti- IgG compared to control subjects ( = 0.02) and a non-significant difference for seropositivity ( = 0.41). All participants were negative for IgM anti-. Demographic parameters did not significantly affect these seroprevalence frequencies ( > 0.05). IL-10 was significantly higher among JIA patients compared to controls ( = 0.007) and seropositive anti- JIA exhibited significantly higher IL-10 levels compared to seronegative ones ( = 0.03). Seropositive anti- IgG JIA patients had a significantly higher disease activity score (JADAS-27) than seronegative anti- IgG cases ( = 0.02). There was a significant positive correlation between anti- IgG and JADAS-27 score ( = 0.009). A significant association was detected between infection and DMARDs including the biological therapies ( < 0.05). Overall, this study supports a possible association between infection and JIA, IL-10, disease activity score, and DMARDs therapies. It is possible that IL-10 plays a role in the development of JIA and contributes to persistent asymptomatic infection with in JIA patients. As a result, a recommendation for screening tests for infection among JIA patients is crucial before and during commencing DMARDs therapies and closely monitoring early signs of infection.