Willard-Mack Cynthia L
Huntingdon Life Sciences, Mettlers Road, East Millstone, NJ 08875-2360, USA.
Toxicol Pathol. 2006;34(5):409-24. doi: 10.1080/01926230600867727.
Lymph nodes are traditionally regarded as having three compartments, the cortex, paracortex and medulla. B and T cells home to separate areas within these compartments, interact with antigen presenting cells, and undergo clonal expansion. This paper provides structural and functional details about how the lymph node brings lymphocytes and antigen presenting cells together. The concept of the lymphoid lobule as the basic functional and anatomic unit of the lymph node is developed and utilized to provide a framework for understanding lymph node pathobiology. Understanding the histomorphologic features of the lymphoid lobule and the role of the reticular meshwork scaffolding of the lymph node and how these related to the cortex, paracortex and medulla provides a unique approach to understanding lymph node structure and function.
传统上认为淋巴结有三个区域，即皮质、副皮质和髓质。B细胞和T细胞归巢至这些区域内的不同部位，与抗原呈递细胞相互作用，并进行克隆扩增。本文提供了关于淋巴结如何将淋巴细胞和抗原呈递细胞聚集在一起的结构和功能细节。淋巴小结作为淋巴结基本功能和解剖单位的概念得以发展并用于为理解淋巴结病理生物学提供一个框架。了解淋巴小结的组织形态学特征、淋巴结网状支架的作用以及它们与皮质、副皮质和髓质的关系，为理解淋巴结的结构和功能提供了一种独特的方法。
