Sobkowski Michal, Stawinski Jacek, Kraszewski Adam
Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland.
Nucleosides Nucleotides Nucleic Acids. 2006;25(12):1377-89. doi: 10.1080/15257770600918888.
Recently, we have proposed a new DP/LP stereochemical notation for P-chiral dinucleoside monophosphate analogues that permits simple correlation between spatial arrangement of the substituents and the configuration at the phosphorus center. As an extension of this work, we present here applications of the DP/LP notation to derivatives containing only one nucleoside unit (e.g., alkyl nucleoside phosphodiesters, nucleoside phosphomonoesters, cyclic phosphate derivatives, nucleoside di-, and triphosphates) and to nonnucleosidic phosphorus compounds.
最近，我们针对P-手性二核苷单磷酸类似物提出了一种新的DP/LP立体化学表示法，该表示法能使取代基的空间排列与磷中心的构型之间建立简单的关联。作为这项工作的延伸，我们在此展示DP/LP表示法在仅含一个核苷单元的衍生物（如烷基核苷磷酸二酯、核苷磷酸单酯、环状磷酸酯衍生物、核苷二磷酸和三磷酸）以及非核苷磷化合物中的应用。
