一种用于P-手性核苷酸类似物的简便表示法的提议。第2部分。二核苷单磷酸类似物。
A proposal for a convenient notation for P-chiral nucleotide analogues. Part 2. Dinucleoside monophosphate analogues.
作者信息
Sobkowski Michal, Stawinski Jacek, Kraszewski Adam
机构信息
Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2006;25(12):1363-75. doi: 10.1080/15257770600918862.
A configuration of ligands around a phosphorus atom in P-chiral dinucleoside monophosphate analogues can be described using DP/LP stereochemical notation, which allows immediate correlation between the notation of configuration and the actual spatial arrangement of the phosphorus ligands. The area of applications of this new stereochemical nomenclature covers dinucleoside units bridged by virtually any type of tri-and tetra-coordinated phosphorus moieties, that is, phosphorothioates, phosphoramidates, phosphoramidites, boranephosphates, methanephosphonates, H-phosphonates, and many others.
磷手性二核苷单磷酸类似物中磷原子周围配体的构型可用DP/LP立体化学符号来描述，该符号能使构型符号与磷配体的实际空间排列直接关联起来。这种新的立体化学命名法的应用领域涵盖了由几乎任何类型的三配位和四配位磷部分桥接的二核苷单元，即硫代磷酸酯、磷酰胺酯、亚磷酰胺酯、硼酸磷酸酯、甲膦酸酯、H-膦酸酯等等。
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