抗胆碱能药物对老年人的长期认知影响。
Long-term cognitive impact of anticholinergic medications in older adults.
作者信息
Bottiggi Kara A, Salazar Juan C, Yu Lei, Caban-Holt Allison M, Ryan Melody, Mendiondo Marta S, Schmitt Frederick A
机构信息
Graduate Center for Gerontology, University of Kentucky, Lexington, KY, USA.
出版信息
Am J Geriatr Psychiatry. 2006 Nov;14(11):980-4. doi: 10.1097/01.JGP.0000224619.87681.71.
OBJECTIVE
The objective of this study was to determine whether chronic use of medications with anticholinergic (AC) properties impact older adults' cognitive functioning.
METHODS
Six years of cognitive test data from two groups of older adults (AC and control) were examined retrospectively (N = 592).
RESULTS
Declines over time were found for the AC group on parts A and B of the Trail Making Test.
CONCLUSION
Physicians prescribing ACs to older adult patients should be aware of their potential effects on psychomotor speed and executive functioning. These cognitive effects may lead to impairments in daily functioning resulting in the need to reevaluate patient medications.
目的
本研究的目的是确定长期使用具有抗胆碱能（AC）特性的药物是否会影响老年人的认知功能。
方法
回顾性分析了两组老年人（AC组和对照组）六年的认知测试数据（N = 592）。
结果
AC组在连线测验A部分和B部分的测试结果随时间出现下降。
结论
给老年患者开AC类药物的医生应意识到此类药物对精神运动速度和执行功能的潜在影响。这些认知影响可能导致日常功能受损，从而需要重新评估患者的用药情况。
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