Lungu Petru Fabian, Lungu Corina Miruna, Ciobica Alin, Balmus Ioana Miruna, Vitalaru Raluca, Mavroudis Ioannis, Dobrin Romeo, Cimpeanu Mirela, Gurzu Irina Luciana
Faculty of Biology, Biology Department, "Alexandru Ioan Cuza" University, 700506 Iasi, Romania.
Faculty of Psychology and Educational Sciences, Psychology Department, "Alexandru Ioan Cuza" University, 700506 Iasi, Romania.
Brain Sci. 2024 Apr 3;14(4):359. doi: 10.3390/brainsci14040359.
The majority of schizophrenia-affected individuals display deficiencies in multiple cognitive domains such as attention, working memory, long-term memory, and learning, deficiencies that are stable throughout the disease. The purpose of this narrative review was to examine the effect of antipsychotics on several cognitive domains affected by schizophrenia. We searched MEDLINE, Elsevier, Scopus, and DOAJ databases for randomized controlled trials and other studies investigating the effects of typical and atypical antipsychotics on cognition in patients with schizophrenia in studies conducted in the last decade. The majority of studies included in this review showed that antipsychotics (especially SGAs) have positive effects on both cognition and general psychopathology of schizophrenia. We mention that treatment with antipsychotic substances represents an ongoing effort of the researchers, who are constantly searching for the best approach to meet the mental health needs of schizophrenia patients. Even with those positive results, it should be noted that more studies are needed in order to fully observe the various effects of certain antipsychotic substances on cognition.
大多数精神分裂症患者在多个认知领域存在缺陷，如注意力、工作记忆、长期记忆和学习能力，这些缺陷在疾病过程中持续存在。本叙述性综述的目的是研究抗精神病药物对精神分裂症所影响的几个认知领域的作用。我们检索了MEDLINE、爱思唯尔、Scopus和DOAJ数据库，以查找过去十年中开展的关于典型和非典型抗精神病药物对精神分裂症患者认知影响的随机对照试验及其他研究。本综述纳入的大多数研究表明，抗精神病药物（尤其是第二代抗精神病药物）对精神分裂症的认知和一般精神病理学均有积极作用。我们提到，使用抗精神病药物进行治疗是研究人员持续进行的工作，他们一直在寻找满足精神分裂症患者心理健康需求的最佳方法。即使有这些积极结果，仍应注意，为了全面观察某些抗精神病药物对认知的各种影响，还需要更多的研究。
