Yashon D, Bingham W G, Friedman S J, Faddoul E M
Surg Neurol. 1975 Jul;4(1):43-51.
Intracellular lysosomal and nonlysosomal enzymes, as well as tissue edema, were measured in spinal cords of monkeys up to 20 days following a 300 gm-cm open injury. Although edema was maximal between six hours and 11 days, enzyme elevation was delayed. Lysosomal enzyme acid cathepsin increased beginning at five days and the beta-glucuronidase and beta-glycerophosphatase increase began at 11 days. Nonlysosomal enzymes were either not elevated or showed a slight rise. These data suggest that edema, one of the secondary damaging factors in spinal injury, is not a result of release of these intracellular enzymes. Also it appears that intracellular enzymes do not participate in early secondary damaging processes in severe spinal injury.
在300克-厘米开放性损伤后的20天内，对猴子脊髓中的细胞内溶酶体酶和非溶酶体酶以及组织水肿进行了测量。尽管水肿在6小时至11天之间达到最大值，但酶的升高出现延迟。溶酶体酶酸性组织蛋白酶从第5天开始增加，β-葡萄糖醛酸酶和β-甘油磷酸酶从第11天开始增加。非溶酶体酶要么没有升高，要么略有升高。这些数据表明，水肿作为脊髓损伤中的继发性损伤因素之一，并非这些细胞内酶释放的结果。此外，似乎细胞内酶不参与严重脊髓损伤的早期继发性损伤过程。
