Hansen Axel Carsten, Jespersen Bo, Kristensen Ingrid Bayer
Aarhus Universitet, Retskemisk Afdeling, Risskov.
Ugeskr Laeger. 2006 Oct 16;168(42):3627-9.
This study was performed to identify the substances used in deliberate self-poisoning and to investigate the epidemiological characteristics of these cases, with the goal of improving prevention of suicides.
The material is made up of 121 cases of deliberate self-poisoning examined at the Institute of Forensic Medicine, University of Aarhus, during the years 1994-2003. The cases were subjected to a forensic autopsy and a toxicological screening for alcohol, drugs, carbon monoxide, cyanide and pesticides.
This material included only 12% of the cases of deliberate self-poisoning in the area serviced by the Institute. 70% were caused by legal drugs and 17% by carbon monoxide. A total of 52 different substances were found. In one third of the cases, two or more substances were found in a lethal concentration. Analgesics and antidepressants were the most common of these. The wide range of substances used was subject to change during the period of investigation. In addition, 40 different substances in therapeutic or only slightly increased concentrations were found. In most cases, the deceased was unemployed, living alone, suffering from a psychiatric disease and addicted to legal or illegal drugs or alcohol. In half the cases, there had been a previous suicide attempt.
It is recommended that only small amounts of drugs be prescribed to persons in danger of committing suicide, as identified by the above-mentioned characteristics.
本研究旨在确定蓄意自我中毒所使用的物质,并调查这些病例的流行病学特征,以期改进自杀预防工作。
材料由1994年至2003年间在奥胡斯大学法医学研究所检查的121例蓄意自我中毒病例组成。这些病例均接受了法医尸检以及酒精、药物、一氧化碳、氰化物和杀虫剂的毒理学筛查。
该材料仅涵盖了该研究所服务区域内蓄意自我中毒病例的12%。70%的病例由合法药物引起,17%由一氧化碳引起。总共发现了52种不同的物质。在三分之一的病例中,发现两种或更多物质处于致死浓度。其中最常见的是镇痛药和抗抑郁药。在所调查期间,所使用物质的种类范围有所变化。此外,还发现了40种处于治疗浓度或仅略有升高浓度的不同物质。在大多数情况下,死者失业、独居、患有精神疾病且对合法或非法药物或酒精成瘾。在一半的病例中,此前曾有过自杀未遂行为。
建议向具有上述特征、有自杀危险的人仅开具少量药物。