Georgia Poison Center, Atlanta, GA, USA.
Department of Emergency Medicine, Emory University, Atlanta, GA, USA.
Basic Clin Pharmacol Toxicol. 2021 May;128(5):699-708. doi: 10.1111/bcpt.13563. Epub 2021 Feb 8.
This retrospective chart review aimed to report the incidence and characteristics of intentional suspected suicide among 13- to 19-year-olds reported to the Georgia Poison Center (GPC) and compared nationally from 2009 to 2018. Of the 19 733 cases reported to the GPC, 74.9% were females. The total number of cases more than doubled from 2009 to 2018, increasing annually by 10%. Majority (90.1%) of the cases occurred in the home, and 60.4% of the cases resulted in either no effect or minor effect. More than half (66.5%) of the cases involved only one substance. Pharmaceuticals made up 94.5% of the substances used, with analgesics accounting for 42.10% and antidepressants at 20.77%. A significant difference was found in substances used between males and females (P < .001). Females were more likely to use analgesics (45.17% vs 32.90%), and males were more likely to use sedatives/hypnotics/antipsychotics (20.45% vs 13.58%). While the majority of the GPC patients were females, the GPC was more likely to have fewer female patients (74.7% vs 75.7%) and more male patients (25.3% vs 24.3%) than other poison centers. Intentional suspected suicide exposures by poisoning are on the rise and higher among females, demonstrating a need for strengthened intervention and prevention strategies.
本回顾性图表研究旨在报告向佐治亚州毒物中心(GPC)报告的 13 至 19 岁青少年故意疑似自杀的发生率和特征,并与 2009 年至 2018 年全国数据进行比较。在向 GPC 报告的 19733 例病例中,有 74.9%为女性。病例总数从 2009 年到 2018 年翻了一番多,每年增长 10%。大多数(90.1%)病例发生在家庭中,60.4%的病例没有或只有轻微影响。超过一半(66.5%)的病例涉及一种物质。所使用的物质中有 94.5%是药品,其中镇痛药占 42.10%,抗抑郁药占 20.77%。男性和女性使用的物质之间存在显著差异(P<.001)。女性更可能使用镇痛药(45.17%比 32.90%),而男性更可能使用镇静剂/催眠剂/抗精神病药(20.45%比 13.58%)。尽管 GPC 的大多数患者是女性,但 GPC 更可能有较少的女性患者(74.7%比 75.7%)和更多的男性患者(25.3%比 24.3%),而其他毒物中心则有更多的女性患者。因中毒导致的故意疑似自杀暴露呈上升趋势,且女性中更高,这表明需要加强干预和预防策略。