Knudsen Stine, Jennum Poul Jørgen
Amtssygehuset i Glostrup, Dansk Center for Søvnmedicin, Klinisk Neurofysiologisk Afdeling, Glostrup.
Ugeskr Laeger. 2006 Oct 23;168(43):3699-704.
Narcolepsy is a common but underdiagnosed sleep disorder characterized by excessive daytime sleepiness and abnormal manifestations of REM sleep: cataplexy, sleep paralysis and hypnagogogic hallucinations. Sleep onset REM periods (SOREMPs) are diagnostic. Within the last five years the pathogenesis has become clearer: narcolepsy is associated with almost total absence of the neuropeptides hypocretin-1 and -2 in the hypothalamus and CSF. A low level of CSF hypocretin is now recognized as a new diagnostic tool. This review provides updated knowledge of narcolepsy.
发作性睡病是一种常见但诊断不足的睡眠障碍，其特征为日间过度嗜睡以及快速眼动睡眠（REM睡眠）的异常表现：猝倒、睡眠瘫痪和入睡前幻觉。睡眠始发快速眼动期（SOREMPs）具有诊断意义。在过去五年中，其发病机制已变得更加清晰：发作性睡病与下丘脑和脑脊液中几乎完全缺乏神经肽下丘脑分泌素-1和-2有关。脑脊液下丘脑分泌素水平低现已被视为一种新的诊断工具。本综述提供了有关发作性睡病的最新知识。
