孕期早期，母体红细胞中的ω-3和ω-6脂肪酸以及血浆脂质浓度与习惯性食用鱼类的饮食习惯有关。
Maternal erythrocyte omega-3 and omega-6 fatty acids, and plasma lipid concentrations, are associated with habitual dietary fish consumption in early pregnancy.
作者信息
Williams Michelle A, Frederick Ihunnaya O, Qiu Chunfang, Meryman Lois J, King Irena B, Walsh Scott W, Sorensen Tanya K
机构信息
Center for Perinatal Studies, Swedish Medical Center, Seattle, WA 98122, USA.
出版信息
Clin Biochem. 2006 Nov;39(11):1063-70. doi: 10.1016/j.clinbiochem.2006.09.008. Epub 2006 Sep 30.
OBJECTIVES
We investigated the relationship between selected maternal erythrocyte omega-3 and omega-6 polyunsaturated fatty acids (PUFA) and plasma lipids in early pregnancy and reported habitual fish consumption during the periconceptional period.
DESIGN AND METHODS
This cohort study included 923 pregnant women who reported periconceptional dietary habits and provided a blood sample before 20 weeks of gestation. PUFA was determined by gas chromatography and plasma lipids by standard enzymatic methods. Differences in erythrocyte PUFA and plasma lipid concentrations were estimated using linear regression.
RESULTS
Mean erythrocyte eicosapentanoic acid and other PUFA content (%/total) were positively associated with frequency of self-reported fish consumption. Arachidonic acid was inversely related with frequent fish consumption (p trend <0.001). Women who consumed fish >twice/week had lower plasma triglyceride (-11.5 mg/dl) and higher HDL-cholesterol (+2.8 mg/dl) concentrations than women consuming fish <once/week.
CONCLUSIONS
These results support findings of inverse relation between fish consumption and preeclampsia risk.
目的
我们研究了孕早期孕妇红细胞中ω-3和ω-6多不饱和脂肪酸（PUFA）与血脂之间的关系，并报告了受孕前后期间的习惯性鱼类消费情况。
设计与方法
这项队列研究纳入了923名报告受孕前后饮食习惯并在妊娠20周前提供血样的孕妇。通过气相色谱法测定PUFA，通过标准酶法测定血脂。使用线性回归估计红细胞PUFA和血脂浓度的差异。
结果
红细胞二十碳五烯酸和其他PUFA含量（%/总量）的平均值与自我报告的鱼类消费频率呈正相关。花生四烯酸与频繁的鱼类消费呈负相关（p趋势<0.001）。每周食用鱼类>两次的女性比每周食用鱼类<一次的女性血浆甘油三酯浓度更低（-11.5mg/dl），高密度脂蛋白胆固醇浓度更高（+2.8mg/dl）。
结论
这些结果支持了鱼类消费与先兆子痫风险呈负相关的研究发现。
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