Mohanty April F, Siscovick David S, Williams Michelle A, Thompson Mary Lou, Burbacher Thomas M, Enquobahrie Daniel A
1Cardiovascular Health Research Unit,Department of Medicine and Department of Epidemiology,University of Washington,Seattle,WA,USA.
2Department of Epidemiology,Harvard School of Public Health,Boston,MA,USA.
Public Health Nutr. 2016 Jul;19(10):1795-803. doi: 10.1017/S136898001500316X. Epub 2015 Dec 2.
To investigate associations of maternal periconceptional shellfish, lean fish and fatty fish intake with risk of pregnancy complications.
In this prospective cohort study, we collected information on intake of seafood subtypes using FFQ. We categorized seafood intake into frequencies of 1 servings/week. We ascertained gestational hypertension, pre-eclampsia, gestational diabetes and preterm birth diagnoses from medical records. Using generalized linear models with a log link, the Poisson family and robust standard errors, we estimated risk ratios and 95 % confidence intervals across seafood intake categories.
The Omega study, a study of risk factors for pregnancy complications among women recruited from prenatal clinics in Washington State, USA, 1996-2008.
The current study included 3279 participants from the Omega study.
Median (interquartile range) shellfish, lean fish and fatty fish intake was 0·3 (0-0·9), 0·5 (0-1·0) and 0·5 (0·1-1·0) servings/week, respectively. Lean fish intake of >1 servings/week (v. <0·2 servings/month) was associated with a 1·55-fold higher risk of preterm birth (95 % CI 1·04, 2·30) and was not associated with the other pregnancy complications. Higher intake of seafood (total or other subtypes) was not associated with pregnancy complications (separately or combined).
Higher intake of lean fish, but not fatty fish or shellfish, was associated with a higher risk of preterm birth; these findings may have significance for preterm birth prevention. Studies of mechanisms and potential contributing factors (including seafood preparation and nutrient/contaminant content) are warranted.
研究孕期贝类、瘦鱼和肥鱼摄入量与妊娠并发症风险之间的关联。
在这项前瞻性队列研究中，我们使用食物频率问卷收集了海鲜亚型摄入量的信息。我们将海鲜摄入量分为每周1份的频率。我们从医疗记录中确定妊娠期高血压、先兆子痫、妊娠期糖尿病和早产的诊断。使用具有对数链接的广义线性模型、泊松族和稳健标准误，我们估计了不同海鲜摄入量类别之间的风险比和95%置信区间。
欧米伽研究，一项关于1996 - 2008年从美国华盛顿州产前诊所招募的女性妊娠并发症危险因素的研究。
本研究纳入了欧米伽研究中的3279名参与者。
贝类、瘦鱼和肥鱼摄入量的中位数（四分位间距）分别为每周0·3（0 - 0·9）份、0·5（0 - 1·0）份和0·5（0·1 - 1·0）份。每周瘦鱼摄入量>1份（对比每月<0·2份）与早产风险高1·55倍相关（95%置信区间1·04，2·30），且与其他妊娠并发症无关。较高的海鲜（总摄入量或其他亚型）摄入量与妊娠并发症（单独或综合）无关。
较高的瘦鱼摄入量，但不是肥鱼或贝类摄入量，与较高的早产风险相关；这些发现可能对早产预防具有重要意义。有必要对机制和潜在促成因素（包括海鲜烹饪方式以及营养成分/污染物含量）进行研究。
