Chen Hanshuang, Zhang Jiqian, Liu Jianqing
College of Physics and Electronic Information, Anhui Normal University, Wuhu, Anhui, 241000, PR China.
Biophys Chem. 2007 Feb;125(2-3):397-402. doi: 10.1016/j.bpc.2006.10.001. Epub 2006 Oct 25.
We have investigated how the external noise would influence the intracellular calcium signaling processes due to the existence of internal noise in small systems. Using chemical Langevin equations, we demonstrate numerically that the behavior of 'system size bi-resonance' induced by internal noise will change with the external noise intensity in different regions, indicating the occurrence of selective effects of external noise. Meanwhile, cell system may also automatically select an optimal cell size to obtain the best performance in the presence of external noise. These results may imply that such selective-effect phenomenon should have some inherent relevance with the distinct deterministic bifurcation features of the system.
我们研究了在小系统中由于内部噪声的存在，外部噪声将如何影响细胞内钙信号传导过程。使用化学朗之万方程，我们通过数值模拟证明，由内部噪声引起的“系统大小双共振”行为会随着不同区域的外部噪声强度而变化，这表明存在外部噪声的选择性效应。同时，细胞系统在存在外部噪声的情况下也可能自动选择最佳细胞大小以获得最佳性能。这些结果可能意味着这种选择性效应现象应该与系统独特的确定性分岔特征有某种内在关联。
