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外部噪声相关性在最佳细胞内钙信号传导中的作用。

Roles of external noise correlation in optimal intracellular calcium signaling.

作者信息

Lang Xiufeng, Li Qianshu

机构信息

State Key Laboratory of Explosion Science and Technology, Beijing Institute of Technology, Beijing, 100081, People's Republic of China.

出版信息

J Chem Phys. 2008 May 28;128(20):205102. doi: 10.1063/1.2920175.

DOI:10.1063/1.2920175
PMID:18513045
Abstract

The dynamics of a minimal calcium model, which is subjected to white noise or colored noise, was investigated. For white noise, coherence of noise-induced calcium oscillations reached a maximum at an optimal noise intensity, characterizing coherence resonance. Higher resonance peaks could be observed at lower noise intensity when a control parameter is tuned to approach a bifurcation point. For colored noise, a maximal coherence of the oscillations was found for suitable values of both the intensity and the correlation time. Moreover, the coherence of the oscillations exhibited two maxima at two values of noise intensity (correlation time) for appropriate noise correlation time (intensity). In addition, a quantitative description of the effects of noise correlation time on the resonance behavior was presented. The resonance behavior, which is induced either by white noise or colored noise, was interpreted by terms of height and relative width of a spectral peak.

摘要

研究了受白噪声或有色噪声影响的最小钙模型的动力学。对于白噪声,噪声诱导的钙振荡的相干性在最佳噪声强度下达到最大值,这表征了相干共振。当控制参数调整到接近分岔点时,在较低噪声强度下可以观察到更高的共振峰。对于有色噪声,在强度和相关时间的合适值下发现振荡的最大相干性。此外,对于适当的噪声相关时间(强度),振荡的相干性在两个噪声强度(相关时间)值处呈现两个最大值。此外,还给出了噪声相关时间对共振行为影响的定量描述。由白噪声或有色噪声诱导的共振行为通过光谱峰的高度和相对宽度来解释。

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